Epidemiology and Burden of Human Papillomavirus and Related Diseases, Molecular Pathogenesis, and Vaccine Evaluation.
Epidemiology and Burden of Human Papillomavirus and Related Diseases, Molecular Pathogenesis, and Vaccine Evaluation.
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人乳头瘤病毒及相关疾病的流行病学和负担、分子发病机制和疫苗评估
DOI：
10.3389/fpubh.2020.552028
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发表时间：
2020
影响因子：
5.2
通讯作者：
Jin T
中科院分区：
文献类型：
--
作者：
Kombe Kombe AJ;Li B;Zahid A;Mengist HM;Bounda GA;Zhou Y;Jin T
人乳头瘤病毒 (HPV) 占 90% 以上的宫颈癌（女性第四大致命癌症），是目前导致女性癌症的最常见病原体。此外，HPV 感染与许多其他疾病有关，包括皮肤和肛门生殖器疣，以及生殖器和上呼吸消化道癌症。这些病变的发生率和患病率有很大差异，具体取决于 HPV 基因型、地区条件、研究人群和采样解剖部位等因素。最近，发现宫颈阴道微生物群的特征与 HPV 相关疾病的发生有关，这提出了一种通过血液和宫颈样本识别高危女性的新方法。总体而言，HPV重新分配数据表明，HPV感染和相关疾病在发展中国家更为普遍。此外，现有的基于病毒样颗粒的疫苗（2价、4价和9价）尽管已被证明有效和安全，但在系统开发成本、运输冷链和致癌HPV变异方面存在一些局限性。此外，疫苗接种计划面临一些挑战，导致HPV感染和相关疾病负担相当大。因此，尽管新的（9 价）疫苗看起来很有希望，但仍需要下一代疫苗以及与 HPV 疫苗接种相关的意识计划和加强免疫预算。
Diagnosed in more than 90% of cervical cancers, the fourth deadliest cancer in women, human papillomavirus (HPV) is currently the most common pathogen responsible for female cancers. Moreover, HPV infection is associated with many other diseases, including cutaneous and anogenital warts, and genital and upper aerodigestive tract cancers. The incidence and prevalence of these pathologies vary considerably depending on factors including HPV genotype, regional conditions, the study population, and the anatomical site sampled. Recently, features of the cervicovaginal microbiota are found to be associated with the incidence of HPV-related diseases, presenting a novel approach to identify high-risk women through both blood and cervical samples. Overall, the HPV repartition data show that HPV infection and related diseases are more prevalent in developing countries. Moreover, the available (2-, 4-, and 9-valent) vaccines based on virus-like particles, despite their proven effectiveness and safety, present some limitations in terms of system development cost, transport cold chain, and oncogenic HPV variants. In addition, vaccination programs face some challenges, leading to a considerable burden of HPV infection and related diseases. Therefore, even though the new (9-valent) vaccine seems promising, next-generation vaccines as well as awareness programs associated with HPV vaccination and budget reinforcements for immunization are needed.
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影响因子：
8.8
作者：
Bruggink, Sjoerd C.;de Koning, Maurits N. C.;Eekhof, Just A. H.
通讯作者：
Eekhof, Just A. H.
DOI：
10.12659/msm.903370
发表时间：
2017-09-04
期刊：
Medical science monitor : international medical journal of experimental and clinical research
影响因子：
--
作者：
Baloch Z;Yasmeen N;Li Y;Zhang W;Lu H;Wu X;Xia X;Yang S
通讯作者：
Yang S
影响因子：
5.4
作者：
Buck, Christopher B.;Cheng, Naiqian;Trus, Benes L.
通讯作者：
Trus, Benes L.
影响因子：
4.7
作者：
Bønløkke S;Blaakær J;Steiniche T;Høgdall E;Jensen SG;Hammer A;Balslev E;Strube ML;Knakkergaard H;Lenz S
通讯作者：
Lenz S
影响因子：
--
作者：
Gurgel AP;Chagas BS;do Amaral CM;Nascimento KC;Leal LR;Silva Neto Jda C;Cartaxo Muniz MT;de Freitas AC
通讯作者：
de Freitas AC