White cells facilitate opposite- and same-sex mating of opaque cells in Candida albicans.
White cells facilitate opposite- and same-sex mating of opaque cells in Candida albicans.
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白细胞促进白色念珠菌中不透明细胞的异性和同性交配
DOI：
10.1371/journal.pgen.1004737
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发表时间：
2014-10
期刊：
影响因子：
4.5
通讯作者：
Huang G
中科院分区：
文献类型：
--
作者：
Tao L;Cao C;Liang W;Guan G;Zhang Q;Nobile CJ;Huang G
真核生物的有性生殖模式是极其多样的。人类真菌病原体白色念珠菌经历了从白色到不透明相的表型转换，以成为交配能力。在这项研究中，我们报告说，功能和形态分化的白色和不透明的细胞在交配过程中表现出协调的行为。虽然白色细胞不能交配，但当用相反交配类型的信息素处理或与相反交配类型的不透明细胞物理相互作用时，它们可以产生性信息素。在共培养系统中，白色细胞释放的信息素诱导不透明细胞形成交配突起，并促进不透明细胞的异性和同性交配。编码信息素前体蛋白的基因的缺失和信息素反应信号通路（Ste 2-MAPK-Cph 1）的失活损害了白色细胞（MTL a）在不透明细胞的性交配中的促进作用。白色和不透明的细胞通过旁分泌信息素信号系统进行交流，创造有利于性交配的环境。两种不同细胞类型之间的这种协调可能是C.白色念珠菌
Modes of sexual reproduction in eukaryotic organisms are extremely diverse. The human fungal pathogen Candida albicans undergoes a phenotypic switch from the white to the opaque phase in order to become mating-competent. In this study, we report that functionally- and morphologically-differentiated white and opaque cells show a coordinated behavior during mating. Although white cells are mating-incompetent, they can produce sexual pheromones when treated with pheromones of the opposite mating type or by physically interacting with opaque cells of the opposite mating type. In a co-culture system, pheromones released by white cells induce opaque cells to form mating projections, and facilitate both opposite- and same-sex mating of opaque cells. Deletion of genes encoding the pheromone precursor proteins and inactivation of the pheromone response signaling pathway (Ste2-MAPK-Cph1) impair the promoting role of white cells (MTL a) in the sexual mating of opaque cells. White and opaque cells communicate via a paracrine pheromone signaling system, creating an environment conducive to sexual mating. This coordination between the two different cell types may be a trade-off strategy between sexual and asexual lifestyles in C. albicans.
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影响因子：
5.2
作者：
Huang G
通讯作者：
Huang G
影响因子：
6.7
作者：
Lin CH;Kabrawala S;Fox EP;Nobile CJ;Johnson AD;Bennett RJ
通讯作者：
Bennett RJ
影响因子：
3.6
作者：
Bennett, Richard J.;Johnson, Alexander D.
通讯作者：
Johnson, Alexander D.
DOI：
10.1038/nrmicro3236
发表时间：
2014-04
期刊：
Nature reviews. Microbiology
影响因子：
--
作者：
通讯作者：
--
DOI：
10.1073/pnas.0605270103
发表时间：
2006-08-22
影响因子：
11.1
作者：
Huang, Guanghua;Wang, Huafeng;Liu, Haoping
通讯作者：
Liu, Haoping