Respiratory Viral Infection-Induced Microbiome Alterations and Secondary Bacterial Pneumonia.
Respiratory Viral Infection-Induced Microbiome Alterations and Secondary Bacterial Pneumonia.
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呼吸道病毒感染诱导的微生物组改变和继发性细菌性肺炎。
DOI：
10.3389/fimmu.2018.02640
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发表时间：
2018
影响因子：
7.3
通讯作者：
Deng JC
中科院分区：
文献类型：
--
作者：
Hanada S;Pirzadeh M;Carver KY;Deng JC
Influenza and other respiratory viral infections are the most common type of acute respiratory infection. Viral infections predispose patients to secondary bacterial infections, which often have a more severe clinical course. The mechanisms underlying post-viral bacterial infections are complex, and include multifactorial processes mediated by interactions between viruses, bacteria, and the host immune system. Studies over the past 15 years have demonstrated that unique microbial communities reside on the mucosal surfaces of the gastrointestinal tract and the respiratory tract, which have both direct and indirect effects on host defense against viral infections. In addition, antiviral immune responses induced by acute respiratory infections such as influenza are associated with changes in microbial composition and function (“dysbiosis”) in the respiratory and gastrointestinal tract, which in turn may alter subsequent immune function against secondary bacterial infection or alter the dynamics of inter-microbial interactions, thereby enhancing the proliferation of potentially pathogenic bacterial species. In this review, we summarize the literature on the interactions between host microbial communities and host defense, and how influenza, and other acute respiratory viral infections disrupt these interactions, thereby contributing to the pathogenesis of secondary bacterial infections.
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DOI：
10.1016/s1473-3099(06)70466-2
发表时间：
2006-05
期刊：
The Lancet. Infectious diseases
影响因子：
--
作者：
Brundage JF
通讯作者：
Brundage JF
年龄、热量限制和流感感染对小鼠肠道微生物组的影响：年龄相关微生物组变化对流感反应作用的探索性研究。
影响因子：
7.3
作者：
Bartley JM;Zhou X;Kuchel GA;Weinstock GM;Haynes L
通讯作者：
Haynes L
影响因子：
8.3
作者：
Dickson, Robert P.;Erb-Downward, John R.;Curtis, Jeffrey L.
通讯作者：
Curtis, Jeffrey L.
影响因子：
15.5
作者：
Allen EK;Koeppel AF;Hendley JO;Turner SD;Winther B;Sale MM
通讯作者：
Sale MM
影响因子：
3.7
作者：
Bogaert D;Keijser B;Huse S;Rossen J;Veenhoven R;van Gils E;Bruin J;Montijn R;Bonten M;Sanders E
通讯作者：
Sanders E