Ultrabright and multicolorful fluorescence of amphiphilic polyethyleneimine polymer dots for efficiently combined imaging and therapy.
Ultrabright and multicolorful fluorescence of amphiphilic polyethyleneimine polymer dots for efficiently combined imaging and therapy.
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两亲性聚乙烯亚胺聚合物点的超亮多色荧光，用于有效组合成像和治疗
DOI：
10.1038/srep03036
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发表时间：
2013-10-24
影响因子：
4.6
通讯作者：
Liang, Xing-Jie
中科院分区：
文献类型：
--
作者：
Sun, Yun;Cao, Weipeng;Li, Shengliang;Jin, Shubin;Hu, Kelei;Hu, Liming;Huang, Yuanyu;Gao, Xueyun;Wu, Yan;Liang, Xing-Jie
多功能纳米颗粒作为治疗诊断工具，以其独特而有效的方式可视化疾病治疗过程，具有巨大的潜力。然而，传统荧光标记的毒性和功能化的困难限制了它们的广泛应用。最近，许多富含氨基的聚合物已经显示出高的发光荧光，但由于它们的蓝色荧光，很少显示出用于体内成像的潜力。在这里，一个通用的路线已被发现，以构建聚合物为基础的多功能纳米粒子结合成像和药物输送。将弱荧光聚乙烯亚胺（PEI）与疏水性聚丙交酯偶联作为两亲性PEI，构建了具有明亮多色荧光、高载药量的纳米颗粒。与游离紫杉醇相比，载紫杉醇纳米粒显示出显著的治疗效果。同时，纳米颗粒的荧光成像显示在肿瘤周围积聚。这些结果证明了一种新型的基于聚合物的多功能纳米粒子用于成像引导的药物递送。
Multifunctional nanoparticles as theranostic tools hold great potential for its unique and efficient way to visualize the process of disease treatment. However, the toxicity of conventional fluorescent labels and difficulty of functionalization limit their widespread use. Recently, a number of amino-rich polymers have demonstrated high luminescent fluorescence but rarely showed potential for in vivo imaging due to their blue fluorescence. Here, a general route has been found to construct polymer-based multifunctional nanoparticles for combined imaging and drug delivering. The weak fluorescent polyethyleneimine (PEI) has been conjugated with hydrophobic polylactide as the amphiphilic PEI for construction of nanoparticles which showed bright and multicolor fluorescence with high drug loading capacity. The paclitaxel-loaded nanoparticles showed significant therapy effect in contrast to the free paclitaxel. Meanwhile, fluorescence imaging of the nanoparticles showed accumulation around tumor. These results demonstrate a new type of polymer-based multifunctional nanoparticles for imaging-guided drug delivery.
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影响因子：
16.6
作者：
Moon, Joong Ho;McDaniel, William;Hancock, Lawrence E.
通讯作者：
Hancock, Lawrence E.
影响因子：
3.4
作者：
Wu CJ;Gaharwar AK;Schexnailder PJ;Schmidt G
通讯作者：
Schmidt G
影响因子：
10.8
作者：
Dobrovoiskaia, Marina A.;Clogston, Jeffrey D.;Neun, Barry W.;Hall, Jennifer B.;Patri, Anil K.;McNeil, Scott E.
通讯作者：
McNeil, Scott E.
影响因子：
15
作者：
Brown, Sarah D.;Nativo, Paola;Smith, Jo-Ann;Stirling, David;Edwards, Paul R.;Venugopal, Balaji;Flint, David J.;Plumb, Jane A.;Graham, Duncan;Wheate, Nial J.
通讯作者：
Wheate, Nial J.
影响因子：
5.5
作者：
Chen, W;Tomalia, DA;Thomas, JL
通讯作者：
Thomas, JL