Region-Specific Slowing of Alpha Oscillations is Associated with Visual-Perceptual Abilities in Children Born Very Preterm.
Region-Specific Slowing of Alpha Oscillations is Associated with Visual-Perceptual Abilities in Children Born Very Preterm.
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DOI：
10.3389/fnhum.2013.00791
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发表时间：
2013
影响因子：
2.9
通讯作者：
Grunau RE
中科院分区：
文献类型：
--
作者：
Doesburg SM;Moiseev A;Herdman AT;Ribary U;Grunau RE
早产儿（胎龄≤32周）没有严重的智力或神经功能障碍，往往表现出视觉感知能力的选择性缺陷。然而，这些问题背后的神经生理发育的改变仍然知之甚少。最近的研究表明，自发性α振荡在早产儿中减慢，并且非典型α介导的功能网络连接可能是该组视觉感知能力选择性发育困难的基础。本研究提供了第一个源解析分析非常早产儿自发性α振荡的减缓，表明分布在后顶叶和下颞区与视觉感知相关的脑区，以及前额叶皮质区和丘脑的变化。我们还独特地证明，α振荡的减缓与非常早产儿视觉感知能力的选择性困难有关。这些结果表明，特定区域的α振荡减缓有助于选择性发育困难，在这个群体中普遍存在。
Children born very preterm (≤32 weeks gestational age) without major intellectual or neurological impairments often express selective deficits in visual-perceptual abilities. The alterations in neurophysiological development underlying these problems, however, remain poorly understood. Recent research has indicated that spontaneous alpha oscillations are slowed in children born very preterm, and that atypical alpha-mediated functional network connectivity may underlie selective developmental difficulties in visual-perceptual ability in this group. The present study provides the first source-resolved analysis of slowing of spontaneous alpha oscillations in very preterm children, indicating alterations in a distributed set of brain regions concentrated in areas of posterior parietal and inferior temporal regions associated with visual perception, as well as prefrontal cortical regions and thalamus. We also uniquely demonstrate that slowing of alpha oscillations is associated with selective difficulties in visual-perceptual ability in very preterm children. These results indicate that region-specific slowing of alpha oscillations contribute to selective developmental difficulties prevalent in this population.
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