Gaze Following is Related to the Broader Autism Phenotype in a Sex-Specific Way: Building the Case for Distinct Male and Female Autism Phenotypes.
Gaze Following is Related to the Broader Autism Phenotype in a Sex-Specific Way: Building the Case for Distinct Male and Female Autism Phenotypes.
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DOI：
10.1177/2167702617738380
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Scherf KS
中科院分区：
文献类型：
--
作者：
Whyte EM;Scherf KS
考虑到女性的低诊断率，寻找女性自闭症表型是困难的。在这里，我们研究了自闭症的核心特征——眼睛注视处理困难——在发育正常的个体中潜在的性别差异，这些个体在广泛的自闭症表型上存在差异，其中包括自闭症样特征，这些特征在男性和女性中都是常见的、连续分布的、相似的遗传特征。参与者观看了一个演员在一个自然场景中看着许多可能的物体中的一个的复杂图像，并必须识别被凝视的目标物体。在男性中，那些自闭症特征高的人比那些自闭症特征低的人表现出更差的注视。在女性中，目光跟随行为与自闭症特征无关。这些结果表明，缺乏眼睛注视跟随行为是男性自闭症表型的一部分，但可能不是女性自闭症表型的一部分。
The search for a female autism phenotype is difficult, given the low diagnostic rates in females. Here, we studied potential sex differences in a core feature of autism, difficulty with eye gaze processing, among typically developing individuals who vary in the broad autism phenotype, which includes autistic-like traits that are common, continuously distributed, and similarly heritable in males and females. Participants viewed complex images of an actor in a naturalistic scene looking at one of many possible objects and had to identify the target gazed-at object. Among males, those high in autistic-like traits exhibited worse eye gaze following performance than did those low in these traits. Among females, eye gaze following behavior did not vary with autistic-like traits. These results suggest that deficient eye gaze following behavior is part of the broader autism phenotype for males, but may not be a part of the female autism phenotype.
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影响因子：
3.9
作者：
Mandy, William;Chilvers, Rebecca;Skuse, David
通讯作者：
Skuse, David
影响因子：
3.6
作者：
Hiller, Rachel M.;Young, Robyn L.;Weber, Nathan
通讯作者：
Weber, Nathan
影响因子：
--
作者：
Lundstrom, Sebastian;Chang, Zheng;Lichtenstein, Paul
通讯作者：
Lichtenstein, Paul
DOI：
10.1073/pnas.1211070110
发表时间：
2013-03-26
影响因子：
11.1
作者：
Robinson, Elise B.;Lichtenstein, Paul;Ronald, Angelica
通讯作者：
Ronald, Angelica
影响因子：
3.9
作者：
Hoekstra, Rosa A.;Bartels, Meike;Cath, Danielle C.;Boomsma, Dorret I.
通讯作者：
Boomsma, Dorret I.