Neocortical Connectivity during Episodic Memory Formation

Neocortical Connectivity during Episodic Memory Formation
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情景记忆形成过程中的新皮质连接

DOI:
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发表时间:
2006
期刊:
影响因子:
9.8
通讯作者:
Jennifer A. Mangels
Jennifer A. Mangels
中科院分区:
生物学1区
文献类型:
--
作者:
C. Summerfield;M. Greene;T. Wager;T. Egner;J. Hirsch;Jennifer A. Mangels

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在新的情景记忆的形成过程中,丰富的感知信息被捆绑在一起进行长期存储。然而,感官表征(如颜色、物体或个体)被选择进行情景编码的大脑机制目前尚不清楚。我们描述了一个功能性磁共振成像实验,在该实验中,参与者对两类视觉刺激之间的关联进行编码,这些视觉刺激会在层外视觉皮层(面部和房屋)中引起选择性反应。通过连通性分析,我们发现面部和位置敏感体素与左背外侧前额叶皮层之间的血流动力学信号的相关性是成功的脸-屋结合的可靠预测指标。这些数据支持这样一种观点,即在情景编码过程中,源自前额叶皮层的“自上而下”控制信号有助于确定哪些感知信息注定要被绑定到新的情景记忆痕迹中。
During the formation of new episodic memories, a rich array of perceptual information is bound together for long-term storage. However, the brain mechanisms by which sensory representations (such as colors, objects, or individuals) are selected for episodic encoding are currently unknown. We describe a functional magnetic resonance imaging experiment in which participants encoded the association between two classes of visual stimuli that elicit selective responses in the extrastriate visual cortex (faces and houses). Using connectivity analyses, we show that correlation in the hemodynamic signal between face- and place-sensitive voxels and the left dorsolateral prefrontal cortex is a reliable predictor of successful face–house binding. These data support the view that during episodic encoding, “top-down” control signals originating in the prefrontal cortex help determine which perceptual information is fated to be bound into the new episodic memory trace.
DOI: 10.1073/pnas.95.3.906
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