Altered multimodal magnetic resonance parameters of basal nucleus of Meynert in Alzheimer's disease.
Altered multimodal magnetic resonance parameters of basal nucleus of Meynert in Alzheimer's disease.
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DOI：
10.1002/acn3.51176
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发表时间：
2020-10
影响因子：
5.3
通讯作者：
Wang Z
中科院分区：
文献类型：
--
作者：
Zheng W;Li H;Cui B;Liang P;Wu Y;Han X;Li CR;Li K;Wang Z
我们的目的是研究40例AD患者的Meynert基底核（BNM）的灰质体积（GMV）、局部血流量（rCBF）和静息状态功能连接（FC）相对于30例健康对照（HC）的变化。我们定义的基础上，从死后人脑组织化学重建的掩模的BNM。我们使用高分辨率结构图像的基于体素的形态测定法检查了GMV，使用动脉自旋标记成像检查了rCBF，使用已发表的常规检查了全脑FC。我们进行了偏相关分析，以探讨AD患者的认知和生活状态与成像指标的关系。此外，我们采用受试者操作特征分析来计算这些成像标记物的“诊断”准确性。与HC相比，AD显示BNM的GMV较低，rCBF较高，BNM与右侧小脑和小脑的连接性较低。此外，BNM的GMV与AD患者的认知和日常生活状态相关。最后，这些成像标记物预测AD（与HC相比）的准确度（曲线下面积）为0.70至0.86。BNM指标的组合提供了最好的预测精度。通过结合多模式MR成像，我们证实了AD患者的BNM体积萎缩、过度灌注和断开。这些发现支持胆碱能功能障碍作为AD和相关痴呆的病因学标志。
We aimed to examine how gray matter volume (GMV), regional blood flow (rCBF), and resting‐state functional connectivity (FC) of the basal nucleus of Meynert (BNM) are altered in 40 patients with AD, relative to 30 healthy controls (HCs). We defined the BNM on the basis of a mask histochemically reconstructed from postmortem human brains. We examined GMV with voxel‐based morphometry of high‐resolution structural images, rCBF with arterial spin labeling imaging, and whole‐brain FC with published routines. We performed partial correlations to explore how the imaging metrics related to cognitive and living status in patients with AD. Further, we employed receiver operating characteristic analysis to compute the “diagnostic” accuracy of these imaging markers. AD relative to HC showed lower GMV and higher rCBF of the BNM as well as lower BNM connectivity with the right insula and cerebellum. In addition, the GMVs of BNM were correlated with cognitive and daily living status in AD. Finally, these imaging markers predicted AD (vs. HC) with an accuracy (area under the curve) of 0.70 to 0.86. Combination of BNM metrics provided the best prediction accuracy. By combining multimode MR imaging, we demonstrated volumetric atrophy, hyperperfusion, and disconnection of the BNM in AD. These findings support cholinergic dysfunction as an etiological marker of AD and related dementia.
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影响因子：
4.2
作者：
Grothe M;Heinsen H;Teipel S
通讯作者：
Teipel S
影响因子：
4.2
作者：
George S;Mufson EJ;Leurgans S;Shah RC;Ferrari C;deToledo-Morrell L
通讯作者：
deToledo-Morrell L
DOI：
10.1073/pnas.0308627101
发表时间：
2004-03-30
影响因子：
11.1
作者：
Greicius, MD;Srivastava, G;Menon, V
通讯作者：
Menon, V
影响因子：
5.7
作者：
Dai, Zhengjia;Yan, Chaogan;He, Yong
通讯作者：
He, Yong
使用联合独立成分分析绘制阿尔茨海默病的联合灰质和白质减少图
影响因子：
2.5
作者：
Guo, Xiaojuan;Han, Yuan;Yao, Li
通讯作者：
Yao, Li