Influenza virus evolution, host adaptation, and pandemic formation.

Influenza virus evolution, host adaptation, and pandemic formation.
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DOI:
10.1016/j.chom.2010.05.009
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发表时间:
2010-06-25
影响因子:
30.3
通讯作者:
Kash JC
Kash JC
中科院分区:
医学1区
文献类型:
--
作者:
Taubenberger JK;Kash JC

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新兴或“重新出现”病毒疾病继续构成重大的全球公共卫生威胁。原型是流感病毒,是人类呼吸道感染和死亡率的主要原因。流感病毒会引起人畜共患感染并适应人类,从而导致新病毒的持续传播和出现。病毒在一个宿主中进化的机制,引起人畜共患感染并适应新宿主物种,但仍未降生。在这里,我们回顾了其储层宿主中流感病毒的演变,并讨论与将新病毒引入人类引起大流传学和建立季节性病毒相关的遗传变化。
Newly emerging or `re-emerging' viral diseases continue to pose significant global public health threats. Prototypic are influenza viruses that are major causes of human respiratory infections and mortality. Influenza viruses can cause zoonotic infections and adapt to humans leading to sustained transmission and emergence of novel viruses. Mechanisms by which viruses evolve in one host, cause zoonotic infection and adapt to a new host species remain unelucidated. Here we review evolution of influenza A viruses in their reservoir hosts and discuss genetic changes associated with introduction of novel viruses into humans leading to pandemics and the establishment of seasonal viruses.
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