Changes in adiponectin:leptin ratio among older adults with obesity following a 12-month exercise and diet intervention.
Changes in adiponectin:leptin ratio among older adults with obesity following a 12-month exercise and diet intervention.
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DOI：
10.1038/s41387-022-00207-1
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发表时间：
2022-06-02
影响因子：
6.1
通讯作者：
Ard, Jamy D.
中科院分区：
文献类型：
--
作者：
Senkus, Katelyn E.;Crowe-White, Kristi M.;Bolland, Anneliese C.;Locher, Julie L.;Ard, Jamy D.
过度肥胖的特征在于脂肪因子分泌的改变，使得循环瘦素浓度随着脂联素的减少而增加。脂联素：瘦素（AL）比值是一种新出现的脂肪组织（AT）功能障碍的生物标志物。低AL比率可能提示AT功能障碍，因此心脏代谢疾病风险升高。这项辅助研究调查了社区居住的肥胖老年人的AL比率与心脏代谢健康之间的关系，以及12个月的运动和饮食干预对AL比率变化的影响。参与者（n = 163，70.2 ± 4.7岁，38.0%男性）被随机分配到仅运动组、运动+营养密集体重维持组（运动+体重维持）或运动+营养密集热量限制500 kcal/d组（运动+有意减肥）（clinicaltrials.gov #NCT00955903）。在基线和12个月时，通过磁共振成像（MRI）和双能X线吸收测定法（DXA）、人体测量学和心脏代谢生物标志物评估了总体和局部肥胖。在所有参与者中，AL比率与基线时的体重指数、腰围、肥胖指标和胰岛素呈显著负相关（p < 0.05）。仅在女性中，还观察到该比率与高密度脂蛋白胆固醇和炎症生物标志物高敏C反应蛋白和白细胞介素-6之间分别存在显著的正相关和负相关。在控制生物性别的同时，观察到干预组的显著时间相互作用效应（p < 0.05），使得在运动+体重维持组和运动+有意减肥组的参与者中，AL比率从基线到研究完成显著增加。事后分析显示，与其他组相比，运动+有意减肥组在研究完成时表现出显著更大的AL比率（p < 0.05）。结果支持AL比率作为老年人AT功能障碍的指标。此外，研究结果表明，12个月的运动和饮食干预与故意减肥有助于改善该人群的AL比率。
Excess adiposity is characterized by alterations in adipokine secretion such that circulating leptin concentrations are increased with reductions in adiponectin. An emerging biomarker for the assessment of this adipose tissue (AT) dysfunction is the adiponectin:leptin (AL) ratio. A low AL ratio may be suggestive of dysfunctional AT and, consequently, a heightened cardiometabolic disease risk. This ancillary study investigated the relationship between the AL ratio and cardiometabolic health among community-dwelling older adults with obesity, as well as the effects of a 12-month exercise and diet intervention on changes in the AL ratio. Participants (n = 163, 70.2 ± 4.7 years, 38.0% male) were randomized to the exercise only group, exercise + nutrient-dense weight maintenance group (exercise + weight maintenance), or exercise + nutrient-dense caloric restriction of 500 kcal/d group (exercise + intentional weight loss) (clinicaltrials.gov #NCT00955903). Total and regional adiposity as determined by magnetic resonance imaging (MRI) and dual-energy X-ray absorptiometry (DXA), anthropometrics, and cardiometabolic biomarkers were assessed at baseline and 12 months. The AL ratio was significantly (p < 0.05) inversely correlated with body mass index, waist circumference, measures of adiposity, and insulin among all participants at baseline. Among females only, significant positive and inverse correlations were also observed between this ratio and high-density lipoprotein cholesterol and the inflammatory biomarkers high sensitivity C-reactive protein and interleukin-6, respectively. While controlling for biological sex, a significant time by intervention group interaction effect (p < 0.05) was observed such that the AL ratio significantly increased from baseline to study completion among participants in the exercise + weight maintenance group and exercise + intentional weight loss group. Post hoc analysis revealed that the exercise + intentional weight loss group exhibited a significantly greater AL ratio at study completion compared to other groups (p < 0.05 all). Results are in support of the AL ratio as a measure of AT dysfunction among older adults. Furthermore, results suggest that a 12-month exercise and diet intervention with intentional weight loss assists in improving the AL ratio in this population.
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炎症和代谢疾病中的脂肪因子。
DOI：
10.1038/nri2921
发表时间：
2011-02
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
通讯作者：
--
影响因子：
5.8
作者：
Isidori, AM;Strollo, F;Fabbri, A
通讯作者：
Fabbri, A
影响因子：
11.1
作者：
Hellström, L;Wahrenberg, H;Arner, P
通讯作者：
Arner, P
影响因子：
8.9
作者：
Lihn, AS;Pedersen, SB;Richelsen, B
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Richelsen, B
DOI：
10.4093/kdj.2010.34.4.237
发表时间：
2010-08
期刊：
Korean diabetes journal
影响因子：
--
作者：
Jung CH;Rhee EJ;Choi JH;Bae JC;Yoo SH;Kim WJ;Park CY;Mok JO;Kim CH;Lee WY;Oh KW;Park SW;Kim SW
通讯作者：
Kim SW