The Prevalence, Incidence, and Progression of Hand Osteoarthritis in Relation to Body Mass Index, Smoking, and Alcohol Consumption.
The Prevalence, Incidence, and Progression of Hand Osteoarthritis in Relation to Body Mass Index, Smoking, and Alcohol Consumption.
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DOI：
10.3899/jrheum.170026
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发表时间：
2017-09
期刊：
影响因子：
--
通讯作者：
Englund M
中科院分区：
文献类型：
--
作者：
Haugen IK;Magnusson K;Turkiewicz A;Englund M
评估超重/肥胖、吸烟和饮酒与放射学手骨关节炎（OA）患病率和纵向变化的相关程度。纳入了骨关节炎倡议的参与者（n = 1232），其中994人有4年的随访数据。在对手部OA事件的分析中，仅纳入了基线时无手部OA的患者（n = 406）。我们的暴露变量是超重/肥胖[体重指数（BMI），腰围]，吸烟（当前/以前，吸烟包年）和饮酒（每周饮酒）。使用线性和逻辑回归分析，我们分析了基线暴露变量与放射学手OA严重程度、糜烂性手OA、手OA发病率和放射学变化之间的可能相关性。分析调整了年龄，性别和教育。超重或肥胖与手OA无关。在横断面分析中，目前吸烟与手部OA较少相关，而纵向分析表明目前吸烟者手部OA发生率较高（OR 2.20，95%CI 1.02-4.77）。适度饮酒与基线时较高的Kelling-Lawrence总分（1-3杯：1.55，95% CI 0.43-2.67）和4年随访期间增加的总分（4-7杯：0.33，95% CI 0.01-0.64）相关。适度饮酒（1-7杯/周）与糜烂性手部OA的2倍高几率相关，具有统计学显著性。对BMI的额外调整给出了类似的关联强度。超重/肥胖与手部OA无关。吸烟和手OA观察到对比结果，表明缺乏关联。适度饮酒与手部OA严重程度、影像学改变和糜烂性手部OA相关，有待进一步研究。
To estimate the extent that overweight/obesity, smoking, and alcohol are associated with prevalence and longitudinal changes of radiographic hand osteoarthritis (OA). Participants from the Osteoarthritis Initiative (n = 1232) were included, of whom 994 had 4-year followup data. In analyses on incident hand OA, only persons without hand OA at baseline were included (n = 406). Our exposure variables were overweight/obesity [body mass index (BMI), waist circumference], smoking (current/former, smoking pack-yrs), and alcohol consumption (drinks/week). Using linear and logistic regression analyses, we analyzed possible associations between baseline exposure variables and radiographic hand OA severity, erosive hand OA, incidence of hand OA, and radiographic changes. Analyses were adjusted for age, sex, and education. Neither overweight nor obesity were associated with hand OA. Current smoking was associated with less hand OA in cross-sectional analyses, whereas longitudinal analyses suggested higher odds of incident hand OA in current smokers (OR 2.20, 95% CI 1.02–4.77). Moderate alcohol consumption was associated with higher Kellgren-Lawrence sum score at baseline (1–3 drinks: 1.55, 95% CI 0.43–2.67) and increasing sum score during 4-year followup (4–7 drinks: 0.33, 95% CI 0.01–0.64). Moderate alcohol consumption (1–7 drinks/week) was associated with 2-fold higher odds of erosive hand OA, which was statistically significant. Additional adjustment for BMI gave similar strengths of associations. Overweight/obesity were not associated with hand OA. Contrasting results were observed for smoking and hand OA, suggesting lack of association. Moderate alcohol consumption was associated with hand OA severity, radiographic changes, and erosive hand OA, warranting further investigation.
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