Detecting mineral content in turbid medium using nonlinear Raman imaging: feasibility study.

Detecting mineral content in turbid medium using nonlinear Raman imaging: feasibility study.
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DOI:
10.1080/09500340.2011.591507
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发表时间:
2011-01-01
影响因子:
1.3
通讯作者:
Yakovlev VV
Yakovlev VV
中科院分区:
物理与天体物理4区
文献类型:
--
作者:
Arora R;Petrov GI;Noojin GD;Thomas PA;Denton ML;Rockwell BA;Thomas RJ;Yakovlev VV

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Osteoporosis is a bone disease characterized by reduced mineral content with resulting changes in bone architecture, which in turn increases the risk of bone fracture. Raman spectroscopy has an intrinsic sensitivity to the chemical content of the bone, but its application to study bones in vivo is limited due to strong optical scattering in tissue. It has been proposed that Raman excitation with photoacoustic detection can successfully address the problem of chemically specific imaging in deep tissue. In this report, the principal possibility of photoacoustic imaging for detecting mineral content is evaluated.
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