Age-related changes in the organization of spontaneously occurring behaviors.
Age-related changes in the organization of spontaneously occurring behaviors.
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DOI：
10.1016/j.beproc.2022.104713
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发表时间：
2022-09
影响因子：
1.3
通讯作者：
Wallace, D. G.
中科院分区：
文献类型：
--
作者：
Oltmanns, J. R. Osterlund;Schaeffer, E. A.;Blackwell, A. A.;Lake, R. I.;Einhaus, R. M.;Kartje, G. L.;Wallace, D. G.
在一系列物种中，已经记录了与空间和时间处理有关的变化。啮齿动物研究通常调查成年和衰老动物之间的表现差异;然而，早在青春期后就观察到海马和皮质中神经元的进行性丧失。因此，本研究评估了年龄对3个月和10个月大雌性大鼠在旷场和食物保护行为中运动组织的影响，这两项任务先前已将海马和皮质病理学分离。在运动、空间定向和注意力处理的一般测量中观察到与运动相关的差异。当前研究的结果与年龄相关的动机变化和空间信息处理一致，这些变化在生命中发生的时间比之前预期的要早。这些观察结果为未来的研究奠定了基础，评估影响这些与年龄相关的表现差异的干预措施。
Age-related changes in spatial and temporal processing have been documented across a range of species. Rodent studies typically investigate differences in performance between adult and senescent animals; however, progressive loss of neurons in the hippocampus and cortex has been observed to occur as early as after adolescence. Therefore, the current study evaluated the effects of age in three- and ten-month-old female rats on the organization of movement in open field and food protection behaviors, two tasks that have previously dissociated hippocampal and cortical pathology. Age-related differences were observed in general measures of locomotion, spatial orientation, and attentional processing. The results of the current study are consistent with age-related changes in motivation and the processing of spatial information that occur earlier in life than previously anticipated. These observations establish a foundation for future studies evaluating interventions that influence these age-related differences in performance.
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影响因子：
2.9
作者：
Martin, Megan M.;Winter, Shawn S.;Cheatwood, Joseph L.;Carter, Lynniece A.;Jones, Jeana L.;Weathered, Scott L.;Wagner, Steven J.;Wallace, Douglas G.
通讯作者：
Wallace, Douglas G.
影响因子：
4.2
作者：
Calabrese, Francesca;Guidotti, Gianluigi;Riva, Marco A.
通讯作者：
Riva, Marco A.
影响因子：
3.3
作者：
Driscoll, I.;Howard, S. R.;Sutherland, R. J.
通讯作者：
Sutherland, R. J.
影响因子：
3
作者：
Drai, D;Benjamini, Y;Golani, I
通讯作者：
Golani, I
影响因子：
2.7
作者：
Dornan, WA;McCampbell, AR;Gunther, KL
通讯作者：
Gunther, KL