Large, Wide-Neck, Side-Wall Aneurysm Treatment in Canines Using NeuroCURE: A Novel Liquid Embolic.
Large, Wide-Neck, Side-Wall Aneurysm Treatment in Canines Using NeuroCURE: A Novel Liquid Embolic.
复制标题
使用 NeuroCURE：一种新型液体栓塞治疗犬科动物的大型宽颈侧壁动脉瘤。
DOI：
10.1161/svin.123.000857
复制
发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Becker,TimothyA
中科院分区：
文献类型：
--
作者：
Merritt,WilliamC;Norris,Nicholas;Robertson,Sophia;Preul,MarkC;Ducruet,AndrewF;Becker,TimothyA
背景未经治疗的颅内动脉瘤可破裂并导致高发病率和死亡率。尽管有许多获批的血管内动脉瘤治疗器械，但大多数需要双重抗血小板治疗，生物相容性极低，或易于再通。Neurovascular Controlled Uniform Rapid Embolic（NeuroCURE）是一种创新的聚合物凝胶材料，具有长期稳定性、生物相容性和血液相容性，用于治疗大型宽颈动脉瘤。MethodsSsidewall动脉瘤在10只犬中通过手术创建，NeuroCURE通过0.025微导管在单球囊充盈期内注射。在栓塞后和足月前使用Raymond-Roy闭塞分类和定性血流分级量表对动脉瘤治疗进行血管造影评估。对动脉瘤瘤颈稳定性和生物相容性进行组织学评估，以分级血小板/纤维蛋白血栓、内皮化百分比和新生内膜形成。通过NeuroCURE囊内容物、炎症和新生血管生成量表评估动脉瘤囊稳定性。结果3个月时，取出的动脉瘤在动脉瘤颈处显示出光滑的表面，新生内膜几乎完全覆盖。到6个月时，所有动物的瘤颈内皮化均为100%（平均Raymond-Roy闭塞分级为1.2），没有动脉瘤再通或载瘤血管血流受损的情况。生物相容性评估证实缺乏炎症反应，新生血管和血小板/纤维蛋白血栓形成。结论NeuroCURE材料促进宽颈侧壁动脉瘤随着时间的推移进行性闭塞，而不需要双重抗血小板剂。NeuroCURE还促进新生内膜组织填充，而不依赖于血栓形成，从而抵抗动脉瘤再通。NeuroCURE仍然是治疗颅内动脉瘤的一种引人注目的试验用器械。
BackgroundUntreated intracranial aneurysms can rupture and result in high rates of morbidity and mortality. Although there are numerous approved endovascular aneurysm treatment devices, most require dual anti‐platelet therapy, are minimally biocompatible, or are prone to recanalization. Neurovascular Controlled Uniform Rapid Embolic (NeuroCURE) is an innovative polymer gel material with long‐term stability, biocompatibility, and hemocompatibility developed for the treatment of large, wide‐neck aneurysms.MethodsSidewall aneurysms were surgically created in 10 canines and NeuroCURE was injected through a 0.025 microcatheter under a single balloon inflation period. Aneurysm treatment was angiographically assessed post‐embolization and pre‐term with Raymond–Roy occlusion classification and a qualitative flow grade scale. Aneurysm neck stability and biocompatibility was histologically assessed to grade platelet/fibrin thrombus, percent endothelialization, and neointimal formation. Aneurysm sac stability was assessed by NeuroCURE sac content, inflammation, and neo‐angiogenesis scales.ResultsExplanted aneurysms exhibited a smooth surface at the aneurysm neck with nearly complete neointimal coverage at 3‐months. By 6‐months, neck endothelialization was 100% in all animals (average Raymond–Roy occlusion classification of 1.2), with no instances of aneurysm recanalization or parent vessel flow compromise. Biocompatibility assessments verified a lack of inflammatory response, neo‐angiogenesis, and platelet/fibrin thrombus formation.ConclusionThe NeuroCURE material promotes progressive occlusion of wide‐necked side wall aneurysms over time without the need for dual antiplatelet agents. NeuroCURE also promotes neointimal tissue infill without dependence on thrombus formation and thus resists aneurysm recanalization. NeuroCURE remains a compelling investigational device for the treatment of intracranial aneurysms.
登录
查看更多内容
聚（ADP-核糖）合成酶和鸡肢间充质细胞分化。
影响因子：
2.7
作者：
B. Cherney;R. Midura;A. Caplan
通讯作者：
A. Caplan
转录活性 DNA 的亲和分离。
DOI：
10.1016/0006-291x(86)91234-9
发表时间：
1986
影响因子：
3.1
作者：
Roseman,B;Lough,J;Houkom,E;Herman,T
通讯作者：
Herman,T
同步化生肌细胞 S 期对 5-溴脱氧尿苷的敏感性不同。
影响因子：
2.7
作者：
John Lough;Richard Bischoff
通讯作者：
Richard Bischoff
在人类早幼粒细胞白血病细胞系 HL-60 的诱导分化过程中，DNA 链断裂的瞬时形成。
影响因子：
14.9
作者：
F. Farzaneh;R. Meldrum;S. Shall
通讯作者：
S. Shall
诱导细胞分化的蛋白质会在双链 DNA 中产生切口
影响因子：
3.5
作者：
G. Weisinger;A. Korn;L. Sachs
通讯作者：
L. Sachs