Nonresonant powering of injectable nanoelectrodes enables wireless deep brain stimulation in freely moving mice.
Nonresonant powering of injectable nanoelectrodes enables wireless deep brain stimulation in freely moving mice.
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DOI：
10.1126/sciadv.abc4189
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发表时间：
2021-01
期刊：
影响因子：
13.6
通讯作者：
Sitti M
中科院分区：
文献类型：
--
作者：
Kozielski KL;Jahanshahi A;Gilbert HB;Yu Y;Erin Ö;Francisco D;Alosaimi F;Temel Y;Sitti M
磁电纳米电极的无线供电用于自由移动和无转基因小鼠的深部脑刺激。电调节大脑深部的设备已经在神经和精神疾病的管理方面取得了重要突破。这种装置通常是厘米级的，需要手术植入和有线供电，这增加了日常活动期间出血、感染和损伤的风险。使用更小的远程供电材料可以减少侵入性神经调节。在这里，我们提出了可注射的磁电纳米电极，它可以响应外部磁场将电信号无线传输到大脑。这种调制机制不需要对神经组织进行遗传修饰，允许动物在刺激期间自由移动，并使用非共振载波频率。使用这些纳米电极，我们证明了神经元的调制在体外和在体内深部脑靶。我们还表明，局部丘脑底调节促进调制通过基底神经节电路连接的其他地区，导致小鼠的行为变化。磁电材料提供了一种多功能平台技术，用于侵入性较小的深部脑神经调节。
Wireless powering of magnetoelectric nanoelectrodes is used for deep brain stimulation in freely moving and transgene-free mice. Devices that electrically modulate the deep brain have enabled important breakthroughs in the management of neurological and psychiatric disorders. Such devices are typically centimeter-scale, requiring surgical implantation and wired-in powering, which increases the risk of hemorrhage, infection, and damage during daily activity. Using smaller, remotely powered materials could lead to less invasive neuromodulation. Here, we present injectable, magnetoelectric nanoelectrodes that wirelessly transmit electrical signals to the brain in response to an external magnetic field. This mechanism of modulation requires no genetic modification of neural tissue, allows animals to freely move during stimulation, and uses nonresonant carrier frequencies. Using these nanoelectrodes, we demonstrate neuronal modulation in vitro and in deep brain targets in vivo. We also show that local subthalamic modulation promotes modulation in other regions connected via basal ganglia circuitry, leading to behavioral changes in mice. Magnetoelectric materials present a versatile platform technology for less invasive, deep brain neuromodulation.
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影响因子：
17.1
作者：
Marino, Attilio;Arai, Satoshi;Hou, Yanyan;Sinibaldi, Edoardo;Pellegrino, Mario;Chang, Young-Tae;Mazzolai, Barbara;Mattoli, Virgilio;Suzuki, Madoka;Ciofani, Gianni
通讯作者：
Ciofani, Gianni
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通讯作者：
Bueno-Basques, D.
DOI：
10.1016/j.rehab.2015.05.005
发表时间：
2015-09-01
影响因子：
4.6
作者：
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通讯作者：
Lackmy-Vallee, Alexandra
影响因子：
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作者：
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通讯作者：
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