Bone Sclerostin and Dickkopf-related protein-1 are positively correlated with bone mineral density, bone microarchitecture, and bone strength in postmenopausal osteoporosis.
Bone Sclerostin and Dickkopf-related protein-1 are positively correlated with bone mineral density, bone microarchitecture, and bone strength in postmenopausal osteoporosis.
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骨硬化蛋白和 Dickkopf 相关蛋白-1 与绝经后骨质疏松症的骨矿物质密度、骨微结构和骨强度呈正相关
DOI：
10.1186/s12891-021-04365-8
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发表时间：
2021-05-25
影响因子：
2.3
通讯作者：
Youjia X
中科院分区：
文献类型：
--
作者：
Peng J;Dong Z;Hui Z;Aifei W;Lianfu D;Youjia X
Wnt-连环蛋白信号拮抗剂sclerostin和dickkopf相关蛋白-1（Dkk-1）抑制骨形成并参与绝经后骨质疏松症（PO）的发病机制。然而，硬化蛋白和Dkk-1和骨矿物质密度（BMD）的妇女PO之间的关联仍不清楚。本研究旨在确定骨质疏松症患者sclerostin和Dkk-1与BMD、骨微结构和骨强度之间的关系。从76例因股骨颈骨折接受髋关节置换术的中国女性PO的股骨头中获得松质骨标本。采用微型计算机断层扫描（Micro-CT）评估骨小梁的BMD和骨微结构。随后，进行机械测试。最后，通过酶联免疫吸附法（Elisa）测定骨中的硬化素和Dkk-1。同时检测血清离子钙、1型胶原前肽、1型胶原C端β端肽、硬化素和Dkk-1。骨硬化素与血清游离钙、骨硬化素、骨密度、骨体积/组织体积、骨小梁数呈正相关（Tb.N）、最大压缩力和屈服强度（r分别为0.32，0.906，0.355，0.401，0.329，0.355和0.293，P < 0.05），与年龄和小梁间距（Tb.Sp）呈负相关（r分别为-0.755和-0.503，P < 0.05）。骨Dkk-1与血清离子钙、血清Dkk-1、BMD、BV/TV、骨小梁厚度、Tb.N、最大压缩力、屈服强度和杨氏模量呈正相关（r分别为0.38、0.809、0.293、0.293、0.228、0.318、0.352、0.315和0.266，P < 0.05），与年龄和Tb.Sp呈负相关（r分别为-0.56和-0.38，P < 0.05）。血清sclerostin和Dkk-1水平反映骨中sclerostin和Dkk-1的水平。骨硬化素和Dkk-1与骨质疏松妇女的BMD呈正相关，骨硬化素和Dkk-1水平越高，可能预示着更好的BMD、骨微结构和骨强度。潜在的分子机制仍需进一步研究。
Wnt-catenin signaling antagonists sclerostin and dickkopf-related protein-1 (Dkk-1) inhibit bone formation and are involved in the pathogenesis of postmenopausal osteoporosis (PO). However, the association between sclerostin and Dkk-1 and bone mineral density (BMD) in women with PO remains unclear. This study aimed to determine the association between sclerostin and Dkk-1 and BMD, bone microarchitecture, and bone strength in PO. Trabecular bone specimens were obtained from the femoral heads of 76 Chinese women with PO who underwent hip arthroplasty for femoral neck fractures. Micro-computed tomography (Micro-CT) was used to assess the BMD and bone microarchitecture of the trabecular bone. Subsequently, a mechanical test was performed. Finally, sclerostin and Dkk-1 in the bone were measured by enzyme-linked immunosorbent (Elisa) assay. Serum ionized serum ionised calcium, propeptide of type 1 collagen, C-terminal β-telopeptide of type-1 collagen, sclerostin, and Dkk-1 were also detected. Bone sclerostin was positively correlated with serum ionised calcium, serum sclerostin, BMD, bone volume/tissue volume (BV/TV), trabecular number (Tb.N), maximum compressive force, and yield strength (r = 0.32, 0.906, 0.355, 0.401, 0.329, 0.355, and 0.293, respectively, P < 0.05) and negatively correlated with age and trabecular separation (Tb.Sp) (r = − 0.755 and − 0.503, respectively, P < 0.05). Bone Dkk-1 was positively correlated with serum ionised calcium, serum Dkk-1, BMD, BV/TV, trabecular thickness, Tb.N, maximum compressive force, yield strength, and Young’s modulus (r = 0.38, 0.809, 0.293, 0.293, 0.228, 0.318, 0.352, 0.315, and 0.266, respectively, P < 0.05) and negatively correlated with age and Tb.Sp (r = − 0.56 and − 0.38, respectively, P < 0.05). Serum levels of sclerostin and Dkk-1 reflected the levels of sclerostin and Dkk-1 in the bone. Bone sclerostin and Dkk-1 were positively correlated with BMD in women with PO, and higher levels of bone sclerostin and Dkk-1 might predict better BMD, bone microarchitecture, and bone strength. The potential molecular mechanisms still require further study.
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影响因子：
4.1
作者：
O'Brien, Charles A.;Nakashima, Tomoki;Takayanagi, Hiroshi
通讯作者：
Takayanagi, Hiroshi
影响因子：
4.2
作者：
Bellido, Teresita
通讯作者：
Bellido, Teresita
影响因子：
6.2
作者：
McColm, Juliet;Hu, Leijun;Chiang, Alan Y.
通讯作者：
Chiang, Alan Y.
影响因子：
16.6
作者：
Florio M;Gunasekaran K;Stolina M;Li X;Liu L;Tipton B;Salimi-Moosavi H;Asuncion FJ;Li C;Sun B;Tan HL;Zhang L;Han CY;Case R;Duguay AN;Grisanti M;Stevens J;Pretorius JK;Pacheco E;Jones H;Chen Q;Soriano BD;Wen J;Heron B;Jacobsen FW;Brisan E;Richards WG;Ke HZ;Ominsky MS
通讯作者：
Ominsky MS
影响因子：
2.3
作者：
Jäckle K;Kolb JP;Schilling AF;Schlickewei C;Amling M;Rueger JM;Lehmann W
通讯作者：
Lehmann W