Cerebellar development after preterm birth.
Cerebellar development after preterm birth.
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DOI：
10.3389/fcell.2022.1068288
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发表时间：
2022
影响因子：
5.5
通讯作者：
中科院分区：
文献类型：
--
作者：
早产及其并发症和相关的不利因素，包括脑出血，炎症和药物治疗的副作用，是神经发育障碍的主要原因。越来越多的证据表明，早产会影响小脑，小脑是参与运动协调、认知、学习、记忆和社会交流的大脑区域。小脑特别容易受到早产的不利影响，因为关键的小脑发育过程，包括神经祖细胞的增殖，以及神经元的分化和迁移，发生在人类妊娠的第三个月。本文综述了早产及其相关因素对小脑发育的负面影响，重点是介导小脑病理的细胞和分子机制。更好地了解早产影响小脑发育的机制是必要的，开发新的治疗和神经保护策略，以改善认知，行为和运动缺陷的早产受试者。
Preterm birth and its complications and the associated adverse factors, including brain hemorrhage, inflammation, and the side effects of medical treatments, are the leading causes of neurodevelopmental disability. Growing evidence suggests that preterm birth affects the cerebellum, which is the brain region involved in motor coordination, cognition, learning, memory, and social communication. The cerebellum is particularly vulnerable to the adverse effects of preterm birth because key cerebellar developmental processes, including the proliferation of neural progenitors, and differentiation and migration of neurons, occur in the third trimester of a human pregnancy. This review discusses the negative impacts of preterm birth and its associated factors on cerebellar development, focusing on the cellular and molecular mechanisms that mediate cerebellar pathology. A better understanding of the cerebellar developmental mechanisms affected by preterm birth is necessary for developing novel treatment and neuroprotective strategies to ameliorate the cognitive, behavioral, and motor deficits experienced by preterm subjects.
影响因子：
3.4
作者：
Sabir H;Dingley J;Scull-Brown E;Chakkarapani E;Thoresen M
通讯作者：
Thoresen M
影响因子：
5
作者：
Buddington RK;Yakimkova T;Adebiyi A;Chizhikov VV;Iskusnykh IY;Buddington KK
通讯作者：
Buddington KK
影响因子：
4.8
作者：
Kim, Hosung;Gano, Dawn;Ho, Mai-Lan;Guo, Xiaoyue M.;Unzueta, Alisa;Hess, Christopher;Ferriero, Donna M.;Xu, Duan;Barkovich, A. James
通讯作者：
Barkovich, A. James