Circulating alanine transaminase (ALT) and γ-glutamyl transferase (GGT), but not fetuin-A, are associated with metabolic risk factors, at baseline and at two-year follow-up: the prospective Cyprus Metabolism Study.
Circulating alanine transaminase (ALT) and γ-glutamyl transferase (GGT), but not fetuin-A, are associated with metabolic risk factors, at baseline and at two-year follow-up: the prospective Cyprus Metabolism Study.
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DOI：
10.1016/j.metabol.2014.03.008
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发表时间：
2014-06
影响因子：
9.8
通讯作者：
Mantzoros, Christos S.
中科院分区：
文献类型：
--
作者：
Liu, Xiaowen;Hamnvik, Ole-Petter R.;Chamberland, John P.;Petrou, Michael;Gong, Huizhi;Christophi, Costas A.;Christiani, David C.;Kales, Stefanos N.;Mantzoros, Christos S.
为了比较传统的肝脏检查和胎球蛋白A作为心脏代谢风险的预测因子，我们研究了血清丙氨酸转氨酶（ALT）、γ-谷氨酰转移酶（GGT）、天冬氨酸转氨酶（AST）和胎球蛋白A与基线时的人体测量、代谢和心血管参数之间的关系，并前瞻性地随访2年。本研究纳入了塞浦路斯代谢研究中随机入组的616例年轻健康受试者，包括基线评估后2年参与随访研究的所有93例受试者。在横断面研究中，血清ALT和GGT与人体测量、心血管和代谢变量密切相关，而血清AST仅与腰围和腰臀比相关。在未校正模型中，胎球蛋白A与人体测量变量、收缩压（SBP）、胰岛素和评估胰岛素抵抗的稳态模型（HOMA-IR）相关。在完全校正的模型中，血清ALT和GGT水平与总胆固醇和低密度脂蛋白（LDL）胆固醇保持正相关。GGT水平也与甘油三酯相关。ALT水平与胰岛素（r=0.17，p<0.0001）和HOMA-IR（r=0.16，p=0.0001）保持强正相关。血清胎球蛋白-A水平不再与任何变量显著相关。脯氨酸、ALT和GGT是人体测量变量和LDL胆固醇的预测因子，而AST和胎球蛋白A的基线水平在2年随访时不是任何变量的预测因子。我们证实了ALT和GGT水平的相关性，但未能证明胎球蛋白A与年轻健康男性的心脏代谢危险因素之间存在独立的相关性。因此，传统的肝脏检查（LFT）比胎球蛋白-A更好地预测健康年轻人的代谢危险因素。
To comparatively evaluate traditional liver tests and fetuin A as predictors of cardiometabolic risk, we studied associations between serum alanine transaminase (ALT), γ-glutamyl transferase (GGT), aspartate aminotransferase (AST) and fetuin-A and anthropometric, metabolic, and cardiovascular parameters cross-sectionally at baseline, and prospectively, after 2-years of follow-up. 616 randomly enrolled young healthy participants in the Cyprus Metabolism Study, including all 93 subjects who participated in the follow-up study 2 years after baseline assessment, were included in this study. In the cross-sectional study, serum ALT and GGT were strongly correlated with anthropometric, cardiovascular, and metabolic variables, while serum AST was only correlated with waist circumference and waist-to-hip ratio. Fetuin-A was correlated with anthropometric variables, systolic blood pressure (SBP), insulin, and homeostasis model of assessment-insulin resistance (HOMA-IR) in the unadjusted model. In the fully adjusted model, both serum ALT and GGT levels remained positively correlated with total and low-density lipoprotein (LDL) cholesterol. GGT levels also remained correlated with triglycerides. ALT levels remained strongly positively correlated with insulin (r=0.17, p<.0001) and HOMA-IR (r=0.16, p=0.0001). Serum fetuin-A levels were no longer significantly correlated with any variables. Prospectively, ALT and GGT were predictors of anthropometric variables and LDL cholesterol, while baseline levels of AST and fetuin-A were not predictors of any variables at 2-year follow-up. We confirmed associations of ALT and GGT levels but failed to demonstrate an independent association between fetuin-A and cardiometabolic risk factors in young healthy men. Traditional liver tests (LFTs) are thus better than fetuin-A predictors of metabolic risk factors cross-sectionally and prospectively in young healthy adults.
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影响因子：
5.4
作者：
Marchesini, G;Avagnina, S;Vitacolonna, E
通讯作者：
Vitacolonna, E
影响因子：
9.8
作者：
Jenkins, Nathan T.;McKenzie, Jennifer A.;Witkowski, Sarah
通讯作者：
Witkowski, Sarah
影响因子：
7.7
作者：
Marchesini, G;Brizi, M;Melchionda, N
通讯作者：
Melchionda, N
影响因子：
5
作者：
COLDITZ, GA;WILLETT, WC;SPEIZER, FE
通讯作者：
SPEIZER, FE
DOI：
10.1038/oby.2000.79
发表时间：
2000-12-01
期刊：
OBESITY RESEARCH
影响因子：
--
作者：
Brown, CD;Higgins, M;Horan, M
通讯作者：
Horan, M