Racial differences in ocular oxidative metabolism: implications for ocular disease.
Racial differences in ocular oxidative metabolism: implications for ocular disease.
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DOI：
10.1001/archophthalmol.2011.169
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发表时间：
2011-07
期刊：
影响因子：
--
通讯作者：
Beebe DC
中科院分区：
文献类型：
--
作者：
Siegfried CJ;Shui YB;Holekamp NM;Bai F;Beebe DC
比较眼内手术患者眼内不同区域PO2的分布。在进行眼内白内障和/或青光眼手术之前，通过角膜外周穿刺将光学氧传感器引入前房。在所有患者中，外科医生将柔性光纤探针的尖端定位于3个位置：(1)靠近角膜中央内皮，(2)在前房中部，(3)在前房角。在计划进行白内障摘除的患者中，PO2也测量(4)在晶状体前表面和(5)在虹膜后面的后房。采用双尾非配对t检验和多元回归对5个地点的氧测量值进行比较。与白种人患者相比，非洲裔美国患者在所有5个部位的PO2值均显著高于白种人患者。调整年龄增加了这种关联的重要性。调整种族后发现，年龄与中央角膜下PO2升高有关。人眼氧水平的种族差异反映了角膜和晶状体氧化代谢的重要差异，并可能反映了系统生理功能的差异。增加的氧气或氧代谢物可能增加氧化应激、细胞损伤、眼压和发生青光眼的风险。角膜的耗氧量随着年龄的增长而减少。
To compare the PO2 distribution in different regions in the eyes of patients undergoing intraocular surgery. Before initiation of intraocular cataract and/or glaucoma surgery, an optical oxygen sensor was introduced into the anterior chamber via a peripheral corneal paracentesis. The tip of the flexible fiberoptic probe was positioned by the surgeon for 3 measurements in all patients: (1) near the central corneal endothelium, (2) in the mid–anterior chamber, and (3) in the anterior chamber angle. In patients scheduled to undergo cataract extraction, PO2 was also measured (4) at the anterior lens surface and (5) in the posterior chamber just behind the iris. Oxygen measurements at the 5 locations were compared using a 2-tailed unpaired t test and multivariate regression. The PO2 value was significantly higher in African American patients at all 5 locations compared with Caucasian patients. Adjusting for age increased the significance of this association. Adjusting for race revealed that age was associated with increased PO2 beneath the central cornea. Racial differences in oxygen levels in the human eye reflect an important difference in oxidative metabolism in the cornea and lens and may reflect differences in systemic physiologic function. Increased oxygen or oxygen metabolites may increase oxidative stress, cell damage, intraocular pressure, and the risk of developing glaucoma. Oxygen use by the cornea decreases with age.
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影响因子：
--
作者：
LESKE, MC;CONNELL, AMS;HYMAN, L
通讯作者：
HYMAN, L
影响因子：
4.2
作者：
Chang, Stanley
通讯作者：
Chang, Stanley
影响因子：
4.2
作者：
Holekamp, NM;Shui, YB;Beebe, DC
通讯作者：
Beebe, DC
影响因子：
4.1
作者：
Quigley, HA;Broman, AT
通讯作者：
Broman, AT
影响因子：
1.4
作者：
Bonanno, Joseph A.;Clark, Christopher;Alvord, Larry
通讯作者：
Alvord, Larry