Estimation of coronary artery hyperemic blood flow based on arterial lumen volume using angiographic images.
Estimation of coronary artery hyperemic blood flow based on arterial lumen volume using angiographic images.
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DOI：
10.1007/s10554-010-9766-1
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发表时间：
2012-01
影响因子：
2.1
通讯作者：
Wong, Jerry T.
中科院分区：
文献类型：
--
作者：
Molloi, Sabee;Chalyan, David;Le, Huy;Wong, Jerry T.
本研究的目的是开发一种方法来估计充血的血液流量在冠状动脉使用的总和远端管腔体积在猪动物模型。视觉评估冠状动脉疾病的局限性是众所周知的。这些局限性在中间冠状动脉病变中尤其重要，在那里很难确定特定病变是否是缺血的原因。因此，需要使用血管造影图像数据对狭窄严重性进行功能测量。在10只猪（约克郡，25-35 kg）左冠状动脉主干高压注射造影剂后进行冠状动脉造影。在诱导充血后，使用密度测定技术来量化体内的局部流量和管腔体积。另外，3只猪的心脏被铸造和成像死后使用锥形束CT获得管腔容积和相应的冠状动脉的动脉长度。结果表明，冠部充血流量（Q）与冠部管腔容积（V）呈线性关系，Q = 159.08V ~（3/4）（r = 0.98，SEE = 10.59ml/min）。茎充血流量与冠长（L）相关系数Q = 2.89L（r = 0.99，SEE = 8.72ml/min）。这些结果表明，测得的动脉分支长度或管腔体积可以潜在地用于预测动脉树中的预期充血流量。这与在存在狭窄的情况下测量的充血流量结合，可以用于完全基于血管造影数据来预测血流储备分数。
The purpose of this study is to develop a method to estimate the hyperemic blood flow in a coronary artery using the sum of the distal lumen volumes in a swine animal model. The limitations of visually assessing coronary artery disease are well known. These limitations are particularly important in intermediate coronary lesions where it is difficult to determine whether a particular lesion is the cause of ischemia. Therefore, a functional measure of stenosis severity is needed using angiographic image data. Coronary arteriography was performed in 10 swine (Yorkshire, 25–35 kg) after power injection of contrast material into the left main coronary artery. A densitometry technique was used to quantify regional flow and lumen volume in vivo after inducing hyperemia. Additionally, 3 swine hearts were casted and imaged post-mortem using cone-beam CT to obtain the lumen volume and the arterial length of corresponding coronary arteries. Using densitometry, the results showed that the stem hyperemic flow (Q) and the associated crown lumen volume (V) were related by Q = 159.08 V3/4 (r = 0.98, SEE = 10.59 ml/min). The stem hyperemic flow and the associated crown length (L) using cone-beam CT were related by Q = 2.89 L (r = 0.99, SEE = 8.72 ml/min). These results indicate that measured arterial branch lengths or lumen volumes can potentially be used to predict the expected hyperemic flow in an arterial tree. This, in conjunction with measured hyperemic flow in the presence of a stenosis, could be used to predict fractional flow reserve based entirely on angiographic data.
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DOI：
10.1085/jgp.9.6.835
发表时间：
1926-07-20
期刊：
The Journal of general physiology
影响因子：
--
作者：
Murray CD
通讯作者：
Murray CD
影响因子：
37.8
作者：
DEBRUYNE, B;BARTUNEK, J;HEYNDRICKX, GR
通讯作者：
HEYNDRICKX, GR
影响因子：
37.8
作者：
Molloi, S;Ersahin, A;Leung, CY
通讯作者：
Leung, CY
影响因子：
3.8
作者：
HANGIANDREOU, NJ;FOLTS, JD;MISTRETTA, CA
通讯作者：
MISTRETTA, CA
影响因子：
37.8
作者：
Molloi, S;Kassab, GS;Zhou, YF
通讯作者：
Zhou, YF