Intrinsic Connectivity and Family Dynamics: Striatolimbic Markers of Risk and Resilience in Youth at Familial Risk for Mood Disorders.
Intrinsic Connectivity and Family Dynamics: Striatolimbic Markers of Risk and Resilience in Youth at Familial Risk for Mood Disorders.
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DOI：
10.1016/j.bpsc.2022.02.009
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发表时间：
2022-09
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表征(1)情绪和奖励网络中风险和韧性的功能连接性(FC)标记物，以及(2)双相情感障碍(HR-BD)和严重抑郁障碍(HR-MDD)的家庭高危青少年的家庭动态如何与FC相关，可能会促进我们对情绪障碍的神经基础的理解，并导致更有效的干预。对139名年龄为12.9+/−2.7岁的青年(43名HR-BD、46名HR-MDD和50名低危[LR])进行了4.5+/−2.4年的随访。我们研究了区分HR-BD、HR-MDD和LR的纹状-边缘FC的差异，以及弹性(RES)和转化为精神病理学(CVT)的差异。然后，我们检查了风险状况是否会缓和FC-家族功能关联。最后，我们检查了在随访时，HR-BD、HR-MDD和LR之间的FC基线差异是否可以预测Res和CVT。HR-BD组大鼠杏仁核-额中回和背侧纹状体-额中回Fc，HR-MDD组下部杏仁-梭形回和背侧纹状体-中央前回Fc(体素水平p<；0.001，簇级fdr校正p<；0.05)。相对于CVT，RES有更大的杏仁核-眶前叶皮质和腹侧纹状体-背侧扣带前皮质(体素水平p<；0.001，簇级FDR校正p<；0.05)。在所有组中，更大的家族刚性与杏仁核-梭形回功能障碍呈负相关(经FDR校正p=0.017)，双相情感障碍状态的调节作用(HR-BD与HR-MDD p<；0.001；HR-BD与LR p=0.005)。基线FC差异不能预测RES与CVT。这些发现代表了情绪和奖励处理网络中风险和韧性的神经特征，这些网络可能是针对家庭背景量身定做的新干预措施的目标。
Characterizing (1) functional connectivity (FC) markers of risk and resilience in emotion and reward networks and (2) how family dynamics in youth at high familial risk for bipolar disorder (HR-BD) and major depressive disorder (HR-MDD) are related to FC may advance our understanding of the neural underpinnings of mood disorders and lead to more effective interventions. 139 youth (43 HR-BD, 46 HR-MDD, and 50 low risk [LR]) aged 12.9+/−2.7 years were followed for 4.5+/−2.4 years. We characterized differences in striato-limbic FC that distinguished HR-BD, HR-MDD and LR; and resilience (RES) versus conversion to psychopathology (CVT). We then examined whether risk status moderated FC-family function associations. Finally, we examined whether baseline differences in FC between HR-BD, HR-MDD and LR predicted RES versus CVT at follow-up. HR-BD had greater amygdala-middle frontal gyrus and dorsal striatum-middle frontal gyrus FC, and HR-MDD had lower amygdala-fusiform gyrus and dorsal striatum-precentral gyrus FC (voxel-level p<0.001, cluster-level FDR-corrected p<0.05). RES had greater amygdala-orbitofrontal cortex and ventral striatum-dorsal anterior cingulate cortex FC relative to CVT (voxel-level p<0.001, cluster-level FDR-corrected p<0.05). Greater family rigidity was inversely associated with amygdala-fusiform gyrus FC across all groups (FDR-corrected p=0.017), with a moderating effect of bipolar risk status (HR-BD vs. HR-MDD p<0.001; HR-BD versus LR p=0.005). Baseline FC differences did not predict RES versus CVT. Findings represent neural signatures of risk and resilience in emotion and reward processing networks in youth at familial risk for mood disorders that may be targets for novel interventions tailored to the family context.
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