The abrupt development of adult-like grid cell firing in the medial entorhinal cortex.
The abrupt development of adult-like grid cell firing in the medial entorhinal cortex.
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DOI：
10.3389/fncir.2012.00021
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发表时间：
2012
影响因子：
3.5
通讯作者：
Cacucci F
中科院分区：
文献类型：
--
作者：
Wills TJ;Barry C;Cacucci F
理解为特定认知功能（如导航）服务的神经回路的发展仍然是神经科学的核心问题。在这里，我们描述了内侧内嗅皮层中网格细胞的发育，由于它们有规律间隔的放电场的性质，被认为为海马体神经对空间的表征提供了距离度量。栅格细胞在大鼠断奶时出现，大约在3周龄。我们研究了年轻大鼠的网格细胞是否在功能上与成年大鼠的网格细胞相同，或者它们是否遵循逐渐发展的轨迹。我们发现，从最年轻的年龄开始（出生后第19天），观察到可复制的网格放电：网格细胞显示成人样的放电场，这些放电场镶嵌形成局部环境的连贯地图；这张地图是通用的，在不同的环境中保持其内部结构；和成年老鼠一样，年轻老鼠的网格细胞也编码了方向和速度的表征。为了进一步研究导致网格细胞出现的发育过程，我们展示了个体内侧内嗅皮层细胞在网格放电模式出现之前和之后超过1天的记录数据。我们发现射击空间稳定性的增加与网格度的增加相关。
Understanding the development of the neural circuits subserving specific cognitive functions such as navigation remains a central problem in neuroscience. Here, we characterize the development of grid cells in the medial entorhinal cortex, which, by nature of their regularly spaced firing fields, are thought to provide a distance metric to the hippocampal neural representation of space. Grid cells emerge at the time of weaning in the rat, at around 3 weeks of age. We investigated whether grid cells in young rats are functionally equivalent to those observed in the adult as soon as they appear, or if instead they follow a gradual developmental trajectory. We find that, from the very youngest ages at which reproducible grid firing is observed (postnatal day 19): grid cells display adult-like firing fields that tessellate to form a coherent map of the local environment; that this map is universal, maintaining its internal structure across different environments; and that grid cells in young rats, as in adults, also encode a representation of direction and speed. To further investigate the developmental processes leading up to the appearance of grid cells, we present data from individual medial entorhinal cortex cells recorded across more than 1 day, spanning the period before and after the grid firing pattern emerged. We find that increasing spatial stability of firing was correlated with increasing gridness.
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影响因子：
56.9
作者：
Fyhn, M;Molden, S;Moser, MB
通讯作者：
Moser, MB
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