Long-Term Antibacterial Efficacy of Cetylpyridinium Chloride-Montmorillonite Containing PMMA Resin Cement.
Long-Term Antibacterial Efficacy of Cetylpyridinium Chloride-Montmorillonite Containing PMMA Resin Cement.
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DOI：
10.3390/nano13091495
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发表时间：
2023-04-27
期刊：
影响因子：
--
通讯作者：
Van Meerbeek B
中科院分区：
文献类型：
--
作者：
Yoshihara K;Nagaoka N;Makita Y;Yoshida Y;Van Meerbeek B
虽然粘结剂和粘固剂能够粘接修复牙齿，但粘结剂和粘固剂并不具有任何防腐保护作用，因此仍有可能发生龋病复发，降低粘结剂修复的临床寿命。几种抗菌剂已被添加到牙科粘合剂和水泥中，使其具有抗龋性。由于具有额外的治疗效果，这类材料被归类为更严格的市场监管的“牙科组合产品”。我们将常用于口腔卫生的氯化十六烷基吡啶(CPC)引入蒙脱土(CPC-Mont)中，后者作为CPC控释的载体。加入组织调节剂的CPC-Mont已获得日本药品和医疗器械厅(PmontMDA)的批准。为了制备一种临床上有效的具有预防继发性龋齿的抗菌潜力的牙科粘固剂，我们将CPC-Mont引入到PMMA树脂粘固剂中。我们测量了实验用CPC-Mont-PMMA粘固剂的弯曲强度、与牙本质的剪切粘结强度、CPC释放量和生物膜抑制潜力。8wt%和10wt%的CPC-Mont浓度在不降低PMMA水泥力学性能的情况下显示了抗菌潜力。
Despite being able to adhesively restore teeth, adhesives and cement do not possess any anticariogenic protection potential, by which caries recurrence may still occur and reduce the clinical lifetime of adhesive restorations. Several antibacterial agents have been incorporated into dental adhesives and cement to render them anticariogenic. Due to an additional therapeutic effect, such materials are classified as ‘dental combination products’ with more strict market regulations. We incorporated cetylpyridinium chloride (CPC), often used for oral hygiene applications, into montmorillonite (CPC-Mont), the latter to serve as a carrier for controlled CPC release. CPC-Mont incorporated into tissue conditioner has been approved by the Pharmaceuticals and Medical Devices Agency (PmontMDA) in Japan. To produce a clinically effective dental cement with the antibacterial potential to prevent secondary caries, we incorporated CPC-Mont into PMMA resin cement. We measured the flexural strength, shear bond strength onto dentin, CPC release, and the biofilm-inhibition potential of the experimental CPC-Mont-containing PMMA cement. An 8 and 10 wt% CPC-Mont concentration revealed the antibacterial potential without reducing the mechanical properties of the PMMA cement.
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影响因子：
5
作者：
Noronha, Victor T.;Paula, Amauri J.;Duran, Nelson
通讯作者：
Duran, Nelson
DOI：
10.1016/j.ajodo.2005.10.015
发表时间：
2006-02-01
影响因子：
3
作者：
Al-Musallam, TA;Evans, CA;Wu, CD
通讯作者：
Wu, CD
DOI：
10.1111/j.1708-8240.2008.00146.x
发表时间：
2008-01-01
影响因子：
3.2
作者：
Turkun, L. Sebnem;Turkun, Murat;Brugger, Stefan
通讯作者：
Brugger, Stefan
影响因子：
6
作者：
Nikolaidis, Alexandros K.;Achilias, Dimitris S.;Karayannidis, George P.
通讯作者：
Karayannidis, George P.
影响因子：
5.2
作者：
Parija, S;Nayak, SK;Tripathy, SS
通讯作者：
Tripathy, SS