Cell mechanics and the cytoskeleton.

Cell mechanics and the cytoskeleton.
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DOI:
10.1038/nature08908
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发表时间:
2010-01-28
期刊:
影响因子:
64.8
通讯作者:
--
中科院分区:
综合性期刊1区
文献类型:
--
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真核细胞抵抗变形、运输细胞内货物和在运动过程中改变形状的能力取决于细胞骨架,这是一个由丝状聚合物和调节蛋白组成的相互连接的网络。最近的研究表明,内部和外部的物理力都可以通过细胞骨架作用,影响局部的机械性能和细胞行为。现在的注意力集中在细胞骨架网络如何在短时间和长时间尺度上产生、传递和响应机械信号。从这项工作中得出的一个重要见解是,长寿的细胞骨架结构可能是细胞形状、功能和命运的表观遗传决定因素。
The ability of a eukaryotic cell to resist deformation, to transport intracellular cargo and to change shape during movement depends on the cytoskeleton, an interconnected network of filamentous polymers and regulatory proteins. Recent work has demonstrated that both internal and external physical forces can act through the cytoskeleton to affect local mechanical properties and cellular behaviour. Attention is now focused on how cytoskeletal networks generate, transmit and respond to mechanical signals over both short and long timescales. An important insight emerging from this work is that long-lived cytoskeletal structures may act as epigenetic determinants of cell shape, function and fate.
DOI: 10.1371/journal.pone.0004632
发表时间: 2009
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影响因子: 3.7
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