Oxidative Stress Response in Pseudomonas aeruginosa.
Oxidative Stress Response in Pseudomonas aeruginosa.
复制标题
铜绿假单胞菌的氧化应激反应。
DOI：
10.3390/pathogens10091187
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发表时间：
2021-09-14
期刊：
影响因子：
--
通讯作者：
Overhage J
中科院分区：
文献类型：
--
作者：
da Cruz Nizer WS;Inkovskiy V;Versey Z;Strempel N;Cassol E;Overhage J
铜绿假单胞菌是一种革兰氏阴性的环境和人类机会致病菌，对多种不同的环境条件高度适应。它可以引起广泛的严重感染，包括伤口、肺部、尿路和全身感染。这种细菌的高度通用性和致病性归因于它的基因组复杂性，几种毒力因子的表达，以及它对各种抗菌素的内在耐药性。然而，为了茁壮成长并建立感染，铜绿假单胞菌必须克服几个障碍。这些障碍之一是存在由宿主免疫系统产生的氧化剂(如过氧化氢、超氧化物和次氯酸)，或在包括医院在内的各种不同环境中通常用作消毒剂。这些制剂会破坏几个细胞分子，并可能导致细胞死亡。因此，细菌通过改变基因表达并引发几种应激反应来适应这些恶劣的条件，从而在氧化应激下生存。在这里，我们使用PubMed来评估目前关于铜绿假单胞菌采用的氧化应激反应的知识。我们将描述在氧化应激条件下经常差异表达的基因，用于感知和响应氧化应激的途径和蛋白质，以及这些基因表达的变化如何影响铜绿假单胞菌的致病性和毒力。了解这些反应和基因表达的变化对于控制细菌的致病性和开发新的治疗药物至关重要。
Pseudomonas aeruginosa is a Gram-negative environmental and human opportunistic pathogen highly adapted to many different environmental conditions. It can cause a wide range of serious infections, including wounds, lungs, the urinary tract, and systemic infections. The high versatility and pathogenicity of this bacterium is attributed to its genomic complexity, the expression of several virulence factors, and its intrinsic resistance to various antimicrobials. However, to thrive and establish infection, P. aeruginosa must overcome several barriers. One of these barriers is the presence of oxidizing agents (e.g., hydrogen peroxide, superoxide, and hypochlorous acid) produced by the host immune system or that are commonly used as disinfectants in a variety of different environments including hospitals. These agents damage several cellular molecules and can cause cell death. Therefore, bacteria adapt to these harsh conditions by altering gene expression and eliciting several stress responses to survive under oxidative stress. Here, we used PubMed to evaluate the current knowledge on the oxidative stress responses adopted by P. aeruginosa. We will describe the genes that are often differently expressed under oxidative stress conditions, the pathways and proteins employed to sense and respond to oxidative stress, and how these changes in gene expression influence pathogenicity and the virulence of P. aeruginosa. Understanding these responses and changes in gene expression is critical to controlling bacterial pathogenicity and developing new therapeutic agents.
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