Combined use of serum and urinary antibody for diagnosis of tuberculosis.
Combined use of serum and urinary antibody for diagnosis of tuberculosis.
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联合使用血清和尿液抗体诊断结核病。
DOI：
10.1086/376532
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发表时间：
2003
期刊：
影响因子：
--
通讯作者：
Laal,Suman
中科院分区：
文献类型：
--
作者：
Singh,KrishnaK;Dong,Yuxin;Hinds,Laura;Keen,MarcA;Belisle,JohnT;Zolla-Pazner,Susan;Achkar,JacquelineM;Nadas,ArthurJ;Arora,VijayK;Laal,Suman
Efforts to devise immunoassays for tuberculosis (TB) that can be adapted to rapid formats are ongoing. The present study was aimed at determining whether urinary anti-Mycobacterium tuberculosisantibodies are present in patients with TB, to evaluate the feasibility of developing a urine antibody-based diagnostic test. Urinary antibodies directed against the culture filtrate proteins ofM. tuberculosis, MPT 32, and the 81-kDa GlcB protein were detectable in patients with TB, although the sensitivity of antibody detection was lower (53%–64%), compared with serum antibodies (68%–77%). Surprisingly, with all 3 antigens, the use of paired serum and urine samples provided higher sensitivities of antibody detection than either single specimen, and anti-GlcB antibodies were present in the serum and/or urine of 39 (90%) of 43 smear-positive patients with TB. Although, with the current methods and antigens, the level of sensitivity is insufficient to design a urinary antibody diagnostic test, these studies provide the foundation for further studies on the development of a urine antibody-based immunoassay for TB.
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人类免疫缺陷病毒感染中临床前结核病的替代标志物：针对结核分枝杆菌 88 kDa 分泌抗原的抗体。
DOI：
10.1086/514015
发表时间：
1997
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Laal,S;Samanich,KM;Sonnenberg,MG;Belisle,JT;O'Leary,J;Simberkoff,MS;Zolla-Pazner,S
通讯作者：
Zolla-Pazner,S
DOI：
10.1016/0192-0561(94)90033-7
发表时间：
1994-05-01
期刊：
INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY
影响因子：
--
作者：
GHEORGHIU, M
通讯作者：
GHEORGHIU, M
影响因子：
3.1
作者：
K. Samanich;J. Belisle;S. Laal
通讯作者：
S. Laal
评估结核分枝杆菌九种新型蛋白质的血清诊断潜力。
影响因子：
2.1
作者：
Moran,AJ;Treit,JD;Whitney,JL;Abomoelak,B;Houghton,R;Skeiky,YA;Sampaio,DP;Badaró,R;Nano,FE
通讯作者：
Nano,FE
检测尿液中排泄的抗幽门螺杆菌抗体的新快速测试
影响因子：
4.4
作者：
S. Yamamoto;Naomi Uemura;S. Okamoto;S. Yamaguchi;Hiroto Mashiba;T. Tachikawa
通讯作者：
T. Tachikawa