Desynchronization of diurnal rhythms in bipolar disorder and borderline personality disorder.
Desynchronization of diurnal rhythms in bipolar disorder and borderline personality disorder.
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DOI：
10.1038/s41398-018-0125-7
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发表时间：
2018-04-12
影响因子：
6.8
通讯作者：
Goodwin GM
中科院分区：
文献类型：
--
作者：
Carr O;Saunders KEA;Bilderbeck AC;Tsanas A;Palmius N;Geddes JR;Foster R;De Vos M;Goodwin GM
长期以来，人们一直认为双相情感障碍（BD）的昼夜节律受到干扰。这种变化在躁狂或抑郁发作时很明显。然而，对发作之间患者的详细研究很少，与其他精神疾病的比较更是罕见。我们的假设是，昼夜节律的去周期化的证据在BD中是明显的，并且我们可以通过研究边缘型人格障碍（BPD）来测试任何效应的特异性。BD患者（n = 36）、BPD患者（n = 22）和健康志愿者（HC，n = 25）佩戴便携式心率和体动仪，并使用智能手机记录自我评估的情绪评分，每天10次，持续1周。在组内和组间比较心率（HR）、活动和睡眠的平均昼夜模式。在BPD（+3 h）和BD（+1 h）中发现HR昼夜节律相与活动相比较的去极化，但HC中未发现。在所有受试者组中都发现了明确的积极情绪昼夜模式。在BD和BPD中，消极和易激情绪与HR之间的一致性显示了每天四个周期的成分，而在HC中不存在。研究结果突出了BD但特别是BPD的昼夜功能测量的显着不同步，并建议在ultradian频率与消极和烦躁情绪的关联增加。这些发现增强了我们对与BPD和BD相关的潜在生理变化的理解，并为监测和潜在治疗靶点提供了客观标志物。改善情绪稳定是两个患者组管理的转化目标。
It has long been proposed that diurnal rhythms are disturbed in bipolar disorder (BD). Such changes are obvious in episodes of mania or depression. However, detailed study of patients between episodes has been rare and comparison with other psychiatric disorders rarer still. Our hypothesis was that evidence for desynchronization of diurnal rhythms would be evident in BD and that we could test the specificity of any effect by studying borderline personality disorder (BPD). Individuals with BD (n = 36), BPD (n = 22) and healthy volunteers (HC, n = 25) wore a portable heart rate and actigraphy device and used a smart-phone to record self-assessed mood scores 10 times per day for 1 week. Average diurnal patterns of heart rate (HR), activity and sleep were compared within and across groups. Desynchronization in the phase of diurnal rhythms of HR compared with activity were found in BPD (+3 h) and BD (+1 h), but not in HC. A clear diurnal pattern for positive mood was found in all subject groups. The coherence between negative and irritable mood and HR showed a four-cycle per day component in BD and BPD, which was not present in HC. The findings highlight marked de-synchronisation of measured diurnal function in both BD but particularly BPD and suggest an increased association with negative and irritable mood at ultradian frequencies. These findings enhance our understanding of the underlying physiological changes associated with BPD and BD, and suggest objective markers for monitoring and potential treatment targets. Improved mood stabilisation is a translational objective for management of both patient groups.
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影响因子：
5.2
作者：
Tsanas A;Saunders K;Bilderbeck A;Palmius N;Goodwin G;De Vos M
通讯作者：
De Vos M
影响因子：
6.6
作者：
Murray, Greg
通讯作者：
Murray, Greg
DOI：
10.1111/1467-9868.00346
发表时间：
2002-01-01
影响因子：
5.8
作者：
Storey, JD
通讯作者：
Storey, JD
影响因子：
11.3
作者：
Henry, Chantal;Van den Bulke, Donatienne;Leboyer, Marion
通讯作者：
Leboyer, Marion
影响因子：
6.9
作者：
Bradley, A. J.;Webb-Mitchell, R.;Anderson, K. N.
通讯作者：
Anderson, K. N.