The Role of Glucose Transporters in Oral Squamous Cell Carcinoma.
The Role of Glucose Transporters in Oral Squamous Cell Carcinoma.
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DOI：
10.3390/biom11081070
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发表时间：
2021-07-21
期刊：
影响因子：
5.5
通讯作者：
Celentano A
中科院分区：
文献类型：
--
作者：
Botha H;Farah CS;Koo K;Cirillo N;McCullough M;Paolini R;Celentano A
口腔鳞状细胞癌（OSCC）是一种常见的恶性肿瘤，预后差。瓦尔堡效应可以在OSCC中观察到，肿瘤需要强大的葡萄糖供应。葡萄糖转运蛋白（GLUT）和钠-葡萄糖协同转运蛋白（SGLT）在多种恶性肿瘤中过表达，并与治疗抵抗、临床因素和总生存期（OS）差相关。我们进行了一项系统的回顾，以评估GLUT/SGLT表达的差异OSCC和正常的口腔角质形成细胞（NOK），以及它们在OSCC的病理生理和预后的作用。在筛选了781篇论文后，共纳入85篇研究。GLUT-1在OSCC中有规律地表达，并且与NOK相比被发现过表达，高表达与肿瘤分期、治疗抗性和不良预后相关。GLUT-1与肿瘤分级、转移和氟脱氧葡萄糖（FDG）摄取之间没有明确的相关性。GLUT-3的研究不太彻底，但可以在大多数样本中检测到，并且与NOK相比通常过表达。GLUT-3与总生存期（OS）呈负相关，但与其他临床因素相关性的数据不足。仅在少数研究中评价了GLUT-2/GLUT-4/GLUT-8/GLUT-13/SGLT-1/SGLT-2的表达，未检测到显著差异。GLUT 7和14从未在OSCC中进行过评估。总之，数据表明GLUT-1和GLUT-3在OSCC的病理生理学中具有作用，并且代表了有价值的生物标志物，以帮助OSCC诊断和鉴别。其他GLUT研究相对不足，应进一步分析，因为它们可能有望改善患者护理。
Oral squamous cell carcinoma (OSCC) is a prevalent malignancy associated with a poor prognosis. The Warburg effect can be observed in OSCCs, with tumours requiring a robust glucose supply. Glucose transporters (GLUTs) and sodium-glucose co-transporters (SGLTs) are overexpressed in multiple malignancies, and are correlated with treatment resistance, clinical factors, and poor overall survival (OS). We conducted a systematic review to evaluate the differences in GLUT/SGLT expression between OSCC and normal oral keratinocytes (NOK), as well as their role in the pathophysiology and prognosis of OSCC. A total of 85 studies were included after screening 781 papers. GLUT-1 is regularly expressed in OSCC and was found to be overexpressed in comparison to NOK, with high expression correlated to tumour stage, treatment resistance, and poor prognosis. No clear association was found between GLUT-1 and tumour grade, metastasis, and fluorodeoxyglucose (FDG) uptake. GLUT-3 was less thoroughly studied but could be detected in most samples and is generally overexpressed compared to NOK. GLUT-3 negatively correlated with overall survival (OS), but there was insufficient data for correlations with other clinical factors. Expression of GLUT-2/GLUT-4/GLUT-8/GLUT-13/SGLT-1/SGLT-2 was only evaluated in a small number of studies with no significant differences detected. GLUTs 7 and 14 have never been evaluated in OSCC. In conclusion, the data demonstrates that GLUT-1 and GLUT-3 have a role in the pathophysiology of OSCC and represent valuable biomarkers to aid OSCC diagnosis and prognostication. Other GLUTs are comparatively understudied and should be further analysed because they may hold promise to improve patient care.
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