Color Tunable Gd-Zn-Cu-In-S/ZnS Quantum Dots for Dual Modality Magnetic Resonance and Fluorescence Imaging.
Color Tunable Gd-Zn-Cu-In-S/ZnS Quantum Dots for Dual Modality Magnetic Resonance and Fluorescence Imaging.
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用于双模态磁共振和荧光成像的颜色可调 Gd-Zn-Cu-In-S/ZnS 量子点
DOI：
10.1007/s12274-014-0518-8
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发表时间：
2014-11-01
期刊：
影响因子：
9.9
通讯作者：
Chen, Xiaoyuan
中科院分区：
文献类型：
--
作者：
Guo, Weisheng;Yang, Weitao;Wang, Yu;Sun, Xiaolian;Liu, Zhongyun;Zhang, Bingbo;Chang, Jin;Chen, Xiaoyuan
关键词：
无机纳米粒子由于其相对较小的尺寸和特殊的物理化学性质，已被引入生物系统作为体外诊断和体内成像的有用探针。合成了一种新型的Gd-Zn-Cu-In-S/ZnS（GZCIS/ZnS）量子点，并将其应用于磁共振和荧光双模态成像。这种策略允许通过将Gd掺入ZCIS/ZnS量子点中来成功地制造GZCIS/ZnS量子点，以实现极大的MR增强，而不损害初始ZCIS/ZnS量子点的荧光性质。通过调节Zn/Cu的投料比，制备的GZCIS/ZnS量子点在550-725 nm范围内表现出高的T1 MR对比度和“颜色可调”的光致发光（PL）量子产率（QY）。GZCIS/ZnS量子点通过牛血清白蛋白（BSA）包被策略转移到水中。所得到的无镉GZCIS/ZnS量子点显示对HeLa和A549细胞的细胞毒性可忽略不计。荧光和磁共振成像研究成功地进行了体外和体内。结果表明，GZCIS/ZnS量子点可作为一种双模态对比剂，在体内成像时同时产生强的MR对比增强和荧光发射。
Inorganic nanoparticles have been introduced into biological systems as useful probes forin vitrodiagnosis andin vivoimaging, due to their relatively small size and exceptional physical and chemical properties. A new kind of colortunable Gd-Zn-Cu-In-S/ZnS (GZCIS/ZnS) quantum dots (QDs) with stable crystal structure has been successfully synthesized and utilized for magnetic resonance (MR) and fluorescence dual modality imaging. This strategy allows successful fabrication of GZCIS/ZnS QDs by incorporating Gd into ZCIS/ZnS QDs to achieve great MR enhancement without compromising the fluorescence properties of the initial ZCIS/ZnS QDs. The as-prepared GZCIS/ZnS QDs show highT1MR contrast as well as “color-tunable” photoluminescence (PL) in the range of 550–725 nm by adjusting the Zn/Cu feeding ratio with high PL quantum yield (QY). The GZCIS/ZnS QDs were transferred into water via a bovine serum albumin (BSA) coating strategy. The resulting Cd-free GZCIS/ZnS QDs reveal negligible cytotoxicity on both HeLa and A549 cells. Both fluorescence and MR imaging studies were successfully performedin vitroandin vivo. The results demonstrated that GZCIS/ZnS QDs could be a dual-modal contrast agent to simultaneously produce strong MR contrast enhancement as well as fluorescence emission forin vivoimaging.
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