Calcium signaling: a common thread in vertebrate left-right axis development.

Calcium signaling: a common thread in vertebrate left-right axis development.
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DOI:
10.1002/dvdy.21704
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发表时间:
2008-12
影响因子:
2.5
通讯作者:
Chen, Jau-Nian
Chen, Jau-Nian
中科院分区:
生物学3区
文献类型:
--
作者:
Langenbacher, Adam;Chen, Jau-Nian

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在脊椎动物发育过程中,左右轴的建立对于协调内脏器官的相对位置以确保它们适当地发挥功能至关重要。在许多模式生物的研究已经揭示了节点信号上游的调节机制的差异,在左右轴规范的保守途径。本文将总结左右对称性破坏的不同途径,并深入探讨钙在脊椎动物左右轴特化中的多重作用。发展动力学237:3491-3496,2008年。© 2008 Wiley利斯公司
The establishment of a left–right axis during vertebrate development is essential for coordinating the relative positions of the internal organs to ensure that they function appropriately. Studies in numerous model organisms have revealed differences in regulative mechanisms upstream of nodal signaling, a conserved pathway in left–right axis specification. This review will summarize the diverse pathways involved in the break of left–right symmetry and explore in depth the multiple roles of calcium in vertebrate left–right axis specification. Developmental Dynamics 237:3491–3496, 2008. © 2008 Wiley‐Liss, Inc.
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