Effects of dominance status on conditioned defeat and expression of 5-HT1A and 5-HT2A receptors.
Effects of dominance status on conditioned defeat and expression of 5-HT1A and 5-HT2A receptors.
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DOI：
10.1016/j.physbeh.2011.02.033
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发表时间：
2011-08-03
影响因子：
2.9
通讯作者：
Cooper MA
中科院分区：
文献类型：
--
作者：
Morrison KE;Swallows CL;Cooper MA
过去的经验可以改变个人对压力事件的反应。大脑5-羟色胺系统是调节压力相关行为的关键因素，并可能导致应对方式的个体差异。在这项研究中，我们调查是否占主导地位和下属仓鼠不同的社会失败，以及他们的行为反应是否与5-HT 1A和5-HT 2A受体免疫反应性在几个边缘脑区的变化。我们将体重匹配的仓鼠配对，每天进行两周的攻击性接触，使它们形成稳定的优势关系。我们还包括每天暴露于空笼中两周的对照组。在最后一次配对或空笼暴露后24小时，受试者在与更具攻击性的仓鼠的3.5分钟遭遇中被社会击败。社交失败后24小时，在与非攻击性入侵者的5分钟社交互动测试中测试动物的条件性失败。我们收集了条件性失败测试后的大脑，并进行5-HT 1A和5-HT 2A受体的免疫组织化学。我们发现，在条件失败测试中，支配者表现出较少的顺从和防御行为，与下属和控制组相比。此外，与对照组相比，优势组和从属组的基底外侧杏仁核中5-HT 1A免疫阳性细胞的数量都有所增加。下属也有更多的5-HT 1A免疫阳性细胞在背内侧杏仁核比对照组。最后，与对照组相比，优势组下丘脑室旁核中的5-HT 1A免疫阳性细胞较少。我们的研究结果表明，占主导地位的社会地位的结果在一个钝化的条件性失败反应和5-HT 1A受体表达的独特模式，这可能有助于抵抗条件性失败。
Past experience can alter how individuals respond to stressful events. The brain serotonin system is a key factor modulating stress-related behavior and may contribute to individual variation in coping styles. In this study we investigated whether dominant and subordinate hamsters respond differently to social defeat and whether their behavioral responses are associated with changes in 5-HT1A and 5-HT2A receptor immunoreactivity in several limbic brain regions. We paired weight-matched hamsters in daily aggressive encounters for two weeks so that they formed a stable dominance relationship. We also included controls that were exposed to an empty cage each day for two weeks. Twenty-four hours after the final pairing or empty cage exposure, subjects were socially defeated in 3, 5-min encounters with a more aggressive hamster. Twenty-four hours after social defeat, animals were tested for conditioned defeat in a 5-min social interaction test with a non-aggressive intruder. We collected brains following conditioned defeat testing and performed immunohistochemistry for 5-HT1A and 5-HT2A receptors. We found that dominants showed less submissive and defensive behavior at conditioned defeat testing compared to both subordinates and controls. Additionally, both dominants and subordinates had an increased number of 5-HT1A immunopositive cells in the basolateral amygdala compared to controls. Subordinates also had more 5-HT1A immunopositive cells in the dorsal medial amygdala than did controls. Finally, dominants had fewer 5-HT1A immunopositive cells in the paraventricular nucleus of the hypothalamus compared to controls. Our results indicate that dominant social status results in a blunted conditioned defeat response and a distinct pattern of 5-HT1A receptor expression, which may contribute to resistance to conditioned defeat.
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