Cortical depth dependence of the diffusion anisotropy in the human cortical gray matter in vivo.
Cortical depth dependence of the diffusion anisotropy in the human cortical gray matter in vivo.
复制标题
体内人皮质灰质中扩散各向异性的皮质深度依赖性。
DOI：
10.1371/journal.pone.0091424
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Song AW
中科院分区：
文献类型：
--
作者：
Truong TK;Guidon A;Song AW
弥散张量成像（DTI）通常用于研究白质纤维通路，但也可用于评估皮层灰质的微观结构。尽管在体内已经观察到皮层扩散的各向异性，但其对皮层深度的依赖主要是在高分辨率的离体研究中进行的。因此，本研究旨在通过临床3t扫描仪研究人体皮层扩散各向异性对皮层深度的依赖性。具体来说，采用了一种新型的多镜头恒密度螺旋DTI技术，该技术具有运动引起的相位误差的固有校正，可实现高空间分辨率（0.625×0.625×3 mm）和高空间保真度，且没有扫描时间损失。结果表明：(1)皮层灰质的扩散各向异性，主要是径向扩散方向，如先前的离体和体内研究所观察到的；(2)皮层各向异性的分数依赖于皮层深度，与先前的离体研究所观察到的一样，皮层中层的值始终高于深部和浅层。这些结果在受试者中是一致的，证明了该技术在体内研究人类皮层扩散各向异性对皮层深度依赖的可行性。
Diffusion tensor imaging (DTI) is typically used to study white matter fiber pathways, but may also be valuable to assess the microstructure of cortical gray matter. Although cortical diffusion anisotropy has previously been observed in vivo, its cortical depth dependence has mostly been examined in high-resolution ex vivo studies. This study thus aims to investigate the cortical depth dependence of the diffusion anisotropy in the human cortex in vivo on a clinical 3 T scanner. Specifically, a novel multishot constant-density spiral DTI technique with inherent correction of motion-induced phase errors was used to achieve a high spatial resolution (0.625×0.625×3 mm) and high spatial fidelity with no scan time penalty. The results show: (i) a diffusion anisotropy in the cortical gray matter, with a primarily radial diffusion orientation, as observed in previous ex vivo and in vivo studies, and (ii) a cortical depth dependence of the fractional anisotropy, with consistently higher values in the middle cortical lamina than in the deep and superficial cortical laminae, as observed in previous ex vivo studies. These results, which are consistent across subjects, demonstrate the feasibility of this technique for investigating the cortical depth dependence of the diffusion anisotropy in the human cortex in vivo.
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