Hydrogels and Cell Based Therapies in Spinal Cord Injury Regeneration.
Hydrogels and Cell Based Therapies in Spinal Cord Injury Regeneration.
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DOI：
10.1155/2015/948040
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发表时间：
2015
影响因子：
4.3
通讯作者：
Salgado AJ
中科院分区：
文献类型：
--
作者：
Assunção-Silva RC;Gomes ED;Sousa N;Silva NA;Salgado AJ
脊髓损伤(SCI)是一种与中枢神经系统(CNS)相关的疾病，目前尚无成功的治疗方法。在过去的几年里，人们探索了基于细胞的治疗方法来修复脊髓损伤，包括使用多能人类干细胞，以及一些成人来源的干细胞和成熟细胞，如间充质干细胞、嗅鞘细胞和雪旺细胞。尽管细胞移植前景看好，但在治疗脊髓损伤时，细胞存活率较低往往会被推翻。或者，通过将细胞移植到生物材料中，不同细胞的治疗作用已被用于组织工程方法。后者的优点是在物理上模拟中枢神经系统组织，同时促进更宽松的环境，以利于细胞生存、生长和分化。本文将讨论细胞治疗和生物材料治疗作为脊髓损伤修复的单一治疗方法的作用。此外，由于脊髓损伤的多因素抑制环境表明组合方法将更有效，本文将强调使用生物材料作为细胞载体的重要性，以及这些有望用于神经组织再生的工具的最新进展和成就。
Spinal cord injury (SCI) is a central nervous system- (CNS-) related disorder for which there is yet no successful treatment. Within the past several years, cell-based therapies have been explored for SCI repair, including the use of pluripotent human stem cells, and a number of adult-derived stem and mature cells such as mesenchymal stem cells, olfactory ensheathing cells, and Schwann cells. Although promising, cell transplantation is often overturned by the poor cell survival in the treatment of spinal cord injuries. Alternatively, the therapeutic role of different cells has been used in tissue engineering approaches by engrafting cells with biomaterials. The latter have the advantages of physically mimicking the CNS tissue, while promoting a more permissive environment for cell survival, growth, and differentiation. The roles of both cell- and biomaterial-based therapies as single therapeutic approaches for SCI repair will be discussed in this review. Moreover, as the multifactorial inhibitory environment of a SCI suggests that combinatorial approaches would be more effective, the importance of using biomaterials as cell carriers will be herein highlighted, as well as the recent advances and achievements of these promising tools for neural tissue regeneration.
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