Widespread brain dysconnectivity associated with psychotic-like experiences in the general population.
Widespread brain dysconnectivity associated with psychotic-like experiences in the general population.
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DOI：
10.1016/j.nicl.2014.01.006
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发表时间：
2014
影响因子：
4.2
通讯作者：
Mittal, Vijay A.
中科院分区：
文献类型：
--
作者：
Orr, Joseph M.;Turner, Jessica A.;Mittal, Vijay A.
越来越清楚的是，精神病是沿着一个连续体发生的。高端是正式的精神病性障碍，如精神分裂症，低端是偶尔出现精神病性症状的个体，但在其他方面是健康的（非临床精神病，NCP）。精神分裂症的特征是大脑区域之间的连接模式改变，但不知道这种连接障碍是否存在于NCP中。在目前的研究中，我们使用功能性磁共振成像（fMRI）比较静息状态下的功能连接NCP个人（n = 25）和健康对照组（n = 27）的四个感兴趣的大脑网络（额顶叶，扣带-鳃盖，默认模式，小脑网络）。与对照组相比，NCP个体显示出默认模式网络区域与额叶区域之间以及所有网络区域与丘脑之间的连接性降低。NCP个人表现出更大的连接相比，控制区域内的额叶控制网络。此外，NCP个体的阳性症状评分与扣带-鳃盖网络和视觉皮层之间的连接呈正相关，与小脑网络和后顶叶皮层和背侧运动前皮层之间的连接呈负相关。连通性与对照组的阳性症状评分无关。综上所述，这些研究结果表明，一系列的异常连接的精神病连续体的基础，并与亚临床精神病的经验，个人代表了理解致病过程的关键人群。我们比较了对照组和非临床精神病（NCP）的静息状态连接。NCP在控制区、默认模式区和小脑区显示出中断的连接。连接中断与阳性症状评分相关。
It is becoming increasingly clear that psychosis occurs along a continuum. At the high end are formal psychotic disorders such as schizophrenia, and at the low-end are individuals who experience occasional psychotic symptoms, but are otherwise healthy (non-clinical psychosis, NCP). Schizophrenia has been shown to be marked by altered patterns of connectivity between brain regions, but it is not known if such dysconnectivity exists in NCP. In the current study we used functional magnetic resonance imaging (fMRI) to compare resting-state functional connectivity in NCP individuals (n = 25) and healthy controls (n = 27) for four brain networks of interest (fronto-parietal, cingulo-opercular, default mode, and cerebellar networks). NCP individuals showed reduced connectivity compared to controls between regions of the default mode network and frontal regions, and between regions in all of the networks and the thalamus. NCP individuals showed greater connectivity compared to controls within regions of frontal control networks. Further, positive symptom scores in NCP individuals were positively correlated with connectivity between the cingulo-opercular network and the visual cortex, and were negatively correlated with connectivity between the cerebellar network and the posterior parietal cortex and dorsal premotor cortex. Connectivity was not correlated with positive symptom scores in controls. Taken together, these findings demonstrate that a spectrum of abnormal connectivity underlies the psychosis continuum, and that individuals with sub-clinical psychotic experiences represent a key population for understanding pathogenic processes. We compared resting state connectivity in controls and non-clinical psychosis (NCP). NCP showed disrupted connectivity in control, default-mode and cerebellum regions. Disrupted connectivity was associated with positive symptom scores.
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
影响因子：
5.7
作者：
Jenkinson, M;Bannister, P;Smith, S
通讯作者：
Smith, S
影响因子：
5.4
作者：
COHEN, JD;SERVANSCHREIBER, D
通讯作者：
SERVANSCHREIBER, D
影响因子：
6.6
作者：
Bluhm, Robyn L.;Miller, Jodi;Williamson, Peter
通讯作者：
Williamson, Peter
影响因子：
4.5
作者：
Armando, Marco;Nelson, Barnaby;Fiori-Nastro, Paolo
通讯作者：
Fiori-Nastro, Paolo