The early inflammatory response after flexor tendon healing: a gene expression and histological analysis.
The early inflammatory response after flexor tendon healing: a gene expression and histological analysis.
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屈肌肌腱愈合后的早期炎症反应：基因表达和组织学分析。
DOI：
10.1002/jor.22575
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发表时间：
2014-05
影响因子：
2.8
通讯作者：
Gelberman, Richard H.
中科院分区：
文献类型：
--
作者：
Manning, Cionne N.;Havlioglu, Necat;Knutsen, Elisa;Sakiyama-Elbert, Shelly E.;Silva, Matthew J.;Thomopoulos, Stavros;Gelberman, Richard H.
尽管在过去的三十年里外科技术取得了进步，肌腱修复仍然倾向于临床结果不佳。以前改善肌腱愈合的尝试集中在愈合的后期阶段（即，增殖和基质合成）。然而，肌腱愈合的早期炎症阶段尚未完全了解，其在愈合过程中的调制尚未研究。因此，这项工作的目的是表征屈肌腱愈合的早期炎症阶段，目的是确定未来治疗的炎症相关目标。采用与临床相同的技术切断并修复犬屈肌腱。监测炎症反应9天。检查免疫细胞群的时间变化和炎症、基质降解和细胞外基质相关因子的基因表达。修复部位细胞群中基因表达模式的改变。在观察到的变化中，最显著的影响是促炎因子IL-1 β的表达上调超过4000倍。虽然炎症反应可能是愈合所必需的，但高水平的促炎细胞因子可能导致附带组织损伤和肌腱愈合受损。这些研究结果表明，未来的肌腱治疗方法考虑愈合的炎症阶段的调制。
Despite advances in surgical techniques over the past three decades, tendon repairs remain prone to poor clinical outcomes. Previous attempts to improve tendon healing have focused on the later stages of healing (i.e., proliferation and matrix synthesis). The early inflammatory phase of tendon healing, however, is not fully understood and its modulation during healing has not yet been studied. Therefore, the purpose of this work was to characterize the early inflammatory phase of flexor tendon healing with the goal of identifying inflammation-related targets for future treatments. Canine flexor tendons were transected and repaired using techniques identical to those used clinically. The inflammatory response was monitored for 9 days. Temporal changes in immune cell populations and gene expression of inflammation-, matrix degradation-, and extracellular matrix-related factors were examined. Gene expression patterns paralleled changes in repair-site cell populations. Of the observed changes, the most dramatic effect was a greater than 4000-fold up-regulation in the expression of the pro-inflammatory factor IL-1β. While an inflammatory response is likely necessary for healing to occur, high levels of pro-inflammatory cytokines may result in collateral tissue damage and impaired tendon healing. These findings suggest that future tendon treatment approaches consider modulation of the inflammatory phase of healing.
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影响因子：
1.8
作者：
Berglund, M.;Hart, D. A.;Wiig, M.
通讯作者：
Wiig, M.
影响因子：
1.9
作者：
GELBERMAN, RH;VANDEBERG, JS;AKESON, WH
通讯作者：
AKESON, WH
DOI：
10.1302/0301-620x.82b7.9892
发表时间：
2000-09-01
影响因子：
--
作者：
Khan, U;Kakar, S;McGrouther, DA
通讯作者：
McGrouther, DA
DOI：
10.1016/0072-968x(76)90007-3
发表时间：
1976-10-01
期刊：
The Hand
影响因子：
--
作者：
Lundborg, G
通讯作者：
Lundborg, G
影响因子：
7.5
作者：
Jackson WM;Nesti LJ;Tuan RS
通讯作者：
Tuan RS