Noncanonical connections between the subiculum and hippocampal CA1.
Noncanonical connections between the subiculum and hippocampal CA1.
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DOI：
10.1002/cne.24024
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发表时间：
2016-12-01
影响因子：
2.5
通讯作者：
Lopez, Alberto J.
中科院分区：
文献类型：
--
作者：
Xu, Xiangmin;Sun, Yanjun;Holmes, Todd C.;Lopez, Alberto J.
传统上认为，海马体结构具有促进兴奋性过程传播的前馈、单向回路组织。虽然从海马CA1到下丘的大量正向投射已经被很好地建立，但越来越多的证据支持从下丘到CA1存在由兴奋性和抑制性成分组成的重要的背向投射通路。基于这些最近更新的解剖学联系，这种背投影可能有助于调节海马CA1区的信息处理。在这里，我们回顾了已发表的有关下丘脑束至CA1背侧投影的解剖学和生理学研究，并提出了最近确凿的解剖学证据，证明存在非典型的下丘脑束至CA1的投射。对这一未被研究的通路的新见解将提高我们对CA1-亚束相互联系的理解，并指导未来关于下丘如何与CA1相互作用来调节海马电路活动和学习记忆行为的研究。在这篇文章中，我们回顾了已发表的关于从下丘脑到CA1的非典型联系的研究，并回顾了最近关于存在兴奋性和抑制性下丘投射到CA1的确凿证据。对这一未被研究的通路的新见解将提高我们对CA1-亚支相互联系的理解，并指导未来的研究。
The hippocampal formation is traditionally viewed as having a feed-forward, unidirectional circuit organization which promotes propagation of excitatory processes. While the substantial forward projection from hippocampal CA1 to the subiculum has been very well established, accumulating evidence supports the existence of a significant back-projection pathway comprised of both excitatory and inhibitory elements from the subiculum to CA1. Based on these recently updated anatomical connections, such a back projection could serve to modulate information processing in hippocampal CA1. Here we review the published anatomical and physiological studies on the subiculum to CA1 back-projection, and present recent conclusive anatomical evidence for the presence of non-canonical subicular projections to CA1. New insights into this under-studied pathway will improve our understanding of reciprocal CA1-subicular connections and guide future studies on how the subiculum interacts with CA1 to regulate hippocampal circuit activity and learning and memory behaviors. In this article, we revisit the published studies on non-canonical connections from the subiculum to CA1, and review recent conclusive evidence for the presence of excitatory and inhibitory subicular projections to CA1. New insights into this under-studied pathway will improve our understanding of reciprocal CA1-subicular connections and guide future studies.
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影响因子：
16.2
作者：
Chevaleyre V;Siegelbaum SA
通讯作者：
Siegelbaum SA
DOI：
10.1073/pnas.1218991110
发表时间：
2013-03-19
影响因子：
11.1
作者：
Deshpande, Aditi;Bergami, Matteo;Berninger, Benedikt
通讯作者：
Berninger, Benedikt
影响因子：
2.9
作者：
FINCH, DM;NOWLIN, NL;BABB, TL
通讯作者：
BABB, TL
影响因子：
2.5
作者：
Knopp, A;Kivi, A;Behr, J
通讯作者：
Behr, J
影响因子：
2.4
作者：
O'Mara, S
通讯作者：
O'Mara, S