Otx expression during lamprey embryogenesis provides insights into the evolution of the vertebrate head and jaw.

Otx expression during lamprey embryogenesis provides insights into the evolution of the vertebrate head and jaw.
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七鳃鳗胚胎发生过程中的 Otx 表达提供了对脊椎动物头部和下颌进化的深入了解。

DOI:
10.1006/dbio.1998.9163
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发表时间:
1999
影响因子:
2.7
通讯作者:
J. Langeland
J. Langeland
中科院分区:
生物学3区
文献类型:
--
作者:
J. Tomsa;J. Langeland

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无颌脊椎动物或无颌脊椎动物,例如七鳃鳗,在有颌脊椎动物或有颌脊椎动物与以文昌鱼为代表的头索动物之间占据着重要的系统发育地位。为了深入了解脊椎动物头部的进化,我们克隆并鉴定了来自七鳃鳗 Petromyzon marinus 的头部特异性基因 Otx 的同源物。该七鳃鳗 Otx 基因是颚口动物 Otx1 和 Otx2 基因的明显系统发育外群。与颚口类动物的同类一样,七鳃鳗 Otx 在整个假定的前脑和中脑中表达。总之,这些结果表明 Otx1 和 Otx2 的分化发生在颌口/无颌分化之后,并且与脊椎动物大脑的起源无关。有趣的是,Otx 也在七鳃鳗的头神经嵴细胞以及第一咽弓的间充质和内胚层成分中表达,这提供了与颚口动物下颌弓同源性的分子证据,并深入了解颚口动物下颌的进化。
Agnathan or jawless vertebrates, such as lampreys, occupy a critical phylogenetic position between the gnathostome or jawed vertebrates and the cephalochordates, represented by amphioxus. In order to gain insight into the evolution of the vertebrate head, we have cloned and characterized a homolog of the head-specific gene Otx from the lamprey Petromyzon marinus. This lamprey Otx gene is a clear phylogenetic outgroup to both the gnathostome Otx1 and Otx2 genes. Like its gnathostome counterparts, lamprey Otx is expressed throughout the presumptive forebrain and midbrain. Together, these results indicate that the divergence of Otx1 and Otx2 took place after the gnathostome/agnathan divergence and does not correlate with the origin of the vertebrate brain. Intriguingly, Otx is also expressed in the cephalic neural crest cells as well as mesenchymal and endodermal components of the first pharyngeal arch in lampreys, providing molecular evidence of homology with the gnathostome mandibular arch and insights into the evolution of the gnathostome jaw.
脊椎动物进化过程中基因的丢失和获得。
DOI: --
发表时间: 1994
期刊: Development (Cambridge, England). Supplement
影响因子: --
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