Laparoscopic optical coherence tomography imaging of human ovarian cancer.
Laparoscopic optical coherence tomography imaging of human ovarian cancer.
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DOI：
10.1016/j.ygyno.2009.05.014
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发表时间：
2009-08
影响因子：
4.7
通讯作者：
Barton JK
中科院分区：
文献类型：
--
作者：
Hariri LP;Bonnema GT;Schmidt K;Winkler AM;Korde V;Hatch KD;Davis JR;Brewer MA;Barton JK
卵巢癌是美国女性癌症相关死亡的第四大原因，主要是由于不可靠的症状和筛查工具没有足够的解决方案而导致的晚期发现。光学相干断层扫描（OCT）是最近出现的一种成像方式，在卵巢癌诊断中具有前景，可提供成像深度达2mm的非破坏性地下成像，接近组织学级分辨率（10-20 μm）。在本研究中，我们开发了第一个腹腔镜OCT （LOCT）装置，评估了LOCT的安全性和可行性，并在体内表征了人类卵巢的微观结构特征。一种定制的LOCT装置专门用于卵巢切除术患者的腹腔镜卵巢成像。将OCT图像与组织病理学相比较，初步确定正常和病理卵巢组织的建筑影像特征。17例主要是围绝经期或绝经后妇女的30个卵巢成功地进行了LOCT成像：16例正常卵巢，5例子宫内膜异位症，3例浆液性囊腺瘤，4例腺癌。每种类型的初步影像学特征揭示了正常绝经后卵巢同质性的质的差异，小的表面下包囊性囊肿的成像能力，以及子宫内膜异位症、囊腺瘤和腺癌的可区分特征。我们提出的发展和成功实施的第一个腹腔镜OCT探头。比较OCT图像和相应的组织病理学，可以描述正常卵巢、子宫内膜异位症和良恶性表面上皮肿瘤的初步显微结构特征。这些结果支持OCT作为进一步评估卵巢癌发病机制的诊断工具和成像方式的潜力。
Ovarian cancer is the fourth leading cause of cancer-related death among women in the US largely due to late detection secondary to unreliable symptomology and screening tools without adequate resolution. Optical coherence tomography (OCT) is a recently emerging imaging modality with promise in ovarian cancer diagnostics, providing non-destructive subsurface imaging at imaging depths up to 2 mm with near-histological grade resolution (10–20 μm). In this study, we developed the first ever laparoscopic OCT (LOCT) device, evaluated the safety and feasibility of LOCT, and characterized the microstructural features of human ovaries in vivo. A custom LOCT device was fabricated specifically for laparoscopic imaging of the ovaries in patients undergoing oophorectomy. OCT images were compared with histopathology to identify preliminary architectural imaging features of normal and pathologic ovarian tissue. Thirty ovaries in 17 primarily peri or post-menopausal women were successfully imaged with LOCT: 16 normal, 5 endometriosis, 3 serous cystadenoma, and 4 adenocarcinoma. Preliminary imaging features developed for each category reveal qualitative differences in the homogeneous character of normal post-menopausal ovary, the ability to image small subsurface inclusion cysts, and distinguishable features for endometriosis, cystadenoma, and adenocarcinoma. We present the development and successful implementation of the first laparoscopic OCT probe. Comparison of OCT images and corresponding histopathology allowed for the description of preliminary microstructural features for normal ovary, endometriosis, and benign and malignant surface epithelial neoplasms. These results support the potential of OCT both as a diagnostic tool and imaging modality for further evaluation of ovarian cancer pathogenesis.
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影响因子：
7.7
作者：
Suter, Melissa J.;Vakoc, Benjamin J.;Yachimski, Patrick S.;Shishkov, Milen;Lauwers, Gregory Y.;Mino-Kenudson, Mari;Bouma, Brett E.;Nishioka, Norman S.;Tearney, Guillermo J.
通讯作者：
Tearney, Guillermo J.
影响因子：
3.5
作者：
Tearney, Guillermo J.;Jang, Ik-Kyung;Bouma, Brett E.
通讯作者：
Bouma, Brett E.
影响因子：
4.7
作者：
Leeper, K;Garcia, R;Paley, P
通讯作者：
Paley, P
影响因子：
45.3
作者：
Lu, KH;Garber, JE;Muto, MG
通讯作者：
Muto, MG
影响因子：
9.8
作者：
Zuluaga, AF;Follen, M;Richards-Kortum, R
通讯作者：
Richards-Kortum, R