ApoE genotype, past adult lead exposure, and neurobehavioral function.
ApoE genotype, past adult lead exposure, and neurobehavioral function.
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DOI：
10.1289/ehp.02110501
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发表时间：
2002-05
影响因子：
10.4
通讯作者：
Todd AC
中科院分区：
文献类型：
--
作者：
Stewart WF;Schwartz BS;Simon D;Kelsey K;Todd AC
我们在这项研究中的目的是确定已知的胫骨铅水平与神经行为测试分数之间的关系是否受载脂蛋白E(ApoE)基因的影响。我们收集了529名前有机铅工人的20项神经行为测试数据，这些工人自上一次职业接触以来平均有16年的时间。我们使用线性回归来模拟20个神经行为测试分数与胫骨铅之间的关系、ApoE基因型的二元变量(即至少有一个epsilon4等位基因与无)以及胫骨铅与ApoE基因型的二元项之间的交互作用项。在测试时，前领班工人的平均年龄为57.6岁；82%的人年龄在65岁以下。在回归分析中，我们观察到一个有统计学意义的系数和一个边缘显著系数单独的载脂蛋白E基因。在20个回归模型中，有19个回归模型的载脂蛋白E和胫骨导联相互作用项的系数为负值。这表明，至少有一个epsilon 4等位基因的个体的胫骨铅与每项神经行为测试之间的关系的斜率比那些没有epsilon 4等位基因的个体更负。交互作用项的19个负系数中有4个具有统计学意义(数字符号、普渡钉板组合、普渡钉板占优势的手、复杂反应时)；其余16个系数中的另外3个系数(符号数字、连线A、Stroop)处于边缘显著(即，p<；0.10)。这项研究表明，不同的人对铅对中枢神经系统(CNS)的长期影响的敏感度可能不同。特别是，铅的持续性中枢神经系统效应可能对至少有一个载脂蛋白E-epsilon4等位基因的个体毒性更大。
Our objective in this study was to determine if the known relation between tibia bone lead levels and neurobehavioral test scores are influenced by the apolipoprotein E (ApoE) genotype. We collected data on 20 neurobehavioral tests in 529 former organolead workers who had an average of 16 years since last occupational exposure to lead. We used linear regression to model the relations between each of 20 neurobehavioral test scores and tibia lead, a binary variable for ApoE genotype (i.e., at least one Epsilon4 allele vs. none), and an interaction term between tibia lead and the binary term for ApoE genotype. At the time of testing, former lead workers were an average of 57.6 years of age; 82% were younger than 65 years. In regression analysis, we observed one statistically significant and one borderline significant coefficient for ApoE genotype alone. Coefficients for the ApoE and tibia lead interaction term were negative in 19 of the 20 regression models. This indicates that the slope for the relation between tibia lead and each neurobehavioral test was more negative for individuals with at least one Epsilon4 allele than for those who did not have an Epsilon4 allele. Four of 19 negative coefficients for the interaction term were statistically significant (digit symbol, Purdue pegboard assembly, Purdue pegboard-dominant hand, complex reaction time); another three of the remaining 16 coefficients (symbol digit, trail-making A, Stroop) were borderline significant (i.e., p < 0.10). This study suggests that individuals may vary in susceptibility to the long-term effects of lead on the central nervous system (CNS). In particular, the persistent CNS effect of lead may be more toxic in individuals who have at least one ApoE-Epsilon4 allele.
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影响因子：
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通讯作者：
AUDESIRK, G
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