Immune-bacteriophage interactions in inflammatory bowel diseases.
Immune-bacteriophage interactions in inflammatory bowel diseases.
复制标题
DOI：
10.1016/j.coviro.2021.04.010
复制
发表时间：
2021-08
影响因子：
5.9
通讯作者：
Round JL
中科院分区：
文献类型：
--
作者：
Gogokhia L;Round JL
炎症性肠病 (IBD)，包括溃疡性结肠炎 (UC) 和克罗恩病 (CD)，受到肠道内细菌和真菌的影响。然而，肠道也是大量病毒颗粒的家园，其中大多数是感染原核生物的病毒，称为噬菌体。虽然目前正在研究使用噬菌体专门针对 IBD 涉及的致病细菌种类，但最近的研究也强调这些病毒颗粒可以影响哺乳动物的免疫系统。 IBD 是一种病因不明的慢性多因素炎症性疾病。这篇综述将重点介绍当前的研究，这些研究表明噬菌体-哺乳动物免疫细胞相互作用可以影响疾病过程，超出其感染细菌的已知作用，这可能会找到治疗或诊断 IBD 的新方法。
Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn’s disease (CD), are influenced by the bacterial and fungal organisms found within the intestine. However, the intestine is also home to a vast number of viral particles, with most of them being viruses that infect prokaryotes, called bacteriophages. While use of bacteriophages to specifically target pathogenic bacterial species involved in IBD is currently under investigation, recent studies have also highlighted that these viral particles can impact the mammalian immune system. IBD is a chronic multi-factorial inflammatory condition with unknown etiology. This review will highlight the current investigations that have revealed that bacteriophage-mammalian immune cell interactions can influence disease processes beyond their known role for infecting bacteria, which might identify novel ways to treat or diagnose IBD.
登录
查看更多内容
影响因子：
4.5
作者：
Gutiérrez B;Domingo-Calap P
通讯作者：
Domingo-Calap P
影响因子：
30.3
作者：
Secor PR;Sweere JM;Michaels LA;Malkovskiy AV;Lazzareschi D;Katznelson E;Rajadas J;Birnbaum ME;Arrigoni A;Braun KR;Evanko SP;Stevens DA;Kaminsky W;Singh PK;Parks WC;Bollyky PL
通讯作者：
Bollyky PL
DOI：
10.1073/pnas.1305923110
发表时间：
2013-06-25
影响因子：
11.1
作者：
Barr, Jeremy J.;Auro, Rita;Rohwer, Forest
通讯作者：
Rohwer, Forest
影响因子：
30.3
作者：
Hsu, Bryan B.;Gibson, Travis E.;Gerber, Georg K.
通讯作者：
Gerber, Georg K.
影响因子：
56.9
作者：
Diard, Mederic;Bakkeren, Erik;Hardt, Wolf-Dietrich
通讯作者：
Hardt, Wolf-Dietrich