Distinct Associations of Deprivation and Threat With Alterations in Brain Structure in Early Childhood.
Distinct Associations of Deprivation and Threat With Alterations in Brain Structure in Early Childhood.
复制标题
剥夺和威胁与幼儿期大脑结构改变的明显关联。
DOI：
10.1016/j.jaac.2023.02.006
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发表时间：
2023
影响因子：
13.3
通讯作者：
Sheridan,MargaretA
中科院分区：
文献类型：
--
作者：
Machlin,Laura;Egger,HelenL;Stein,CherylR;Navarro,Esmeralda;Carpenter,KimberlyLH;Goel,Srishti;Patel,KinjalK;Copeland,WilliamE;Sheridan,MargaretA
目的逆境和精神病理学的维度模型假设剥夺和威胁影响不同的神经生物学通路，如大脑结构。这一假设尚未被纵向检验，也未在幼儿身上得到验证。这项研究测试了在学龄前测量的威胁和剥夺与儿童大脑结构之间的纵向联系。假设威胁与杏仁核和海马皮层下体积有关，剥夺与皮质厚度相关。方法研究包括72名儿童(5-10岁，54.2%的女性参与者)的T1加权扫描。威胁是通过存在家庭暴力、性虐待、身体虐待或邻里暴力来衡量的。剥夺是通过忽视的存在来衡量的。通过全脑顶点分析，控制其他维度(剥夺或威胁)和滋扰协变量，研究剥夺或威胁与大脑结构的关联。提取皮质下体积，并使用多元回归检验相同的相关性。结果Threat与前额叶皮质和其他区域的皮质表面积普遍减少有关。威胁与杏仁核或海马体体积无关。剥夺与枕叶皮质、脑岛和扣带的厚度增加有关。结论研究结果表明，剥夺与儿童早期大脑结构的威胁有明显的关联。威胁与表面积的广泛差异有关，剥夺与皮质厚度的差异有关。这些观察结果与青春期和成年期的研究结果一致，反映了逆境的不同维度是如何不同地影响神经结构的。
ObjectiveThe dimensional model of adversity and psychopathology hypothesizes deprivation and threat impact distinct neurobiological pathways, such as brain structure. This hypothesis has not been examined longitudinally or in young children. This study tested longitudinal associations between threat and deprivation measured in preschool and brain structure in childhood. It was hypothesized that threat would be associated with amygdala and hippocampal subcortical volume and deprivation would be associated with cortical thickness in association cortex.MethodThe study included T1-weighted scans from 72 children (5-10 years old, 54.2% female participants). Threat was measured by the presence of domestic violence, sexual abuse, physical abuse, or neighborhood violence. Deprivation was measured by the presence of neglect. Associations of deprivation or threat with brain structure were examined controlling for other dimension (deprivation or threat) and nuisance covariates using whole-brain vertex-wise analyses. Subcortical volume was extracted, and the same associations were examined using multiple regression.ResultsThreat was associated with widespread decreases in cortical surface area across the prefrontal cortex and other regions. Threat was not associated with amygdala or hippocampal volume. Deprivation was associated with increased thickness in occipital cortex, insula, and cingulate.ConclusionResults suggest distinct associations of deprivation and threat on brain structure in early childhood. Threat is associated with widespread differences in surface area, and deprivation is associated with differences in cortical thickness. These observations are consistent with work in adolescence and adulthood and reflect how dimensions of adversity differentially impact neural structure.
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DOI：
10.1016/j.jaac.2017.01.013
发表时间：
2017-04
影响因子：
13.3
作者：
Busso DS;McLaughlin KA;Brueck S;Peverill M;Gold AL;Sheridan MA
通讯作者：
Sheridan MA
影响因子：
--
作者：
Edmiston, Erin E.;Wang, Fei;Mazure, Carolyn M.;Guiney, Joanne;Sinha, Rajita;Mayes, Linda C.;Blumberg, Hilary P.
通讯作者：
Blumberg, Hilary P.
影响因子：
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作者：
Copeland, William E.;Keeler, Gordon;Costello, E. Jane
通讯作者：
Costello, E. Jane
DOI：
10.1016/j.jaac.2012.12.010
发表时间：
2013-03
影响因子：
13.3
作者：
Roy AK;Fudge JL;Kelly C;Perry JS;Daniele T;Carlisi C;Benson B;Castellanos FX;Milham MP;Pine DS;Ernst M
通讯作者：
Ernst M
DOI：
10.1097/01.chi.0000205705.71194.b8
发表时间：
2006-05-01
影响因子：
13.3
作者：
Egger, HL;Erkanli, A;Angold, A
通讯作者：
Angold, A