Intrinsic functional connectivity of amygdala-based networks in adolescent generalized anxiety disorder.
Intrinsic functional connectivity of amygdala-based networks in adolescent generalized anxiety disorder.
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DOI：
10.1016/j.jaac.2012.12.010
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发表时间：
2013-03
影响因子：
13.3
通讯作者：
Ernst M
中科院分区：
文献类型：
--
作者：
Roy AK;Fudge JL;Kelly C;Perry JS;Daniele T;Carlisi C;Benson B;Castellanos FX;Milham MP;Pine DS;Ernst M
广泛性焦虑症（GAD）通常在青春期开始，并可持续到成年。这种疾病的病理生理机制尚不清楚。最近的证据从静息状态功能磁共振成像（R-fMRI）的研究表明，在成人杏仁核为基础的电路中断，本研究探讨这个问题在青少年广泛性焦虑症。静息状态的fMRI扫描，从15名青少年广泛性焦虑症和20名青少年无焦虑谁组匹配的年龄，性别，扫描仪，和智力。比较各组之间杏仁核中央、基底外侧和浅表分区的功能连接。我们还评估了杏仁核网络功能障碍与焦虑严重程度之间的关系。患有广泛性焦虑症的青少年表现出以杏仁核为基础的内在功能连接网络的中断，包括内侧前额叶皮层、小脑和小脑区域。在广泛性焦虑症组中，焦虑严重程度评分与杏仁核与颞叶回和上级颞回的功能连接呈正相关。有一些证据表明，与那些没有广泛性焦虑症的青少年相比，右基底外侧和中央杏仁核网络的重叠更大（连接模式的差异更小）。这些研究结果表明，青少年广泛性焦虑症表现出杏仁核回路参与情绪处理的改变，类似于成人的研究结果。此外，在参与恐惧处理和内感受状态编码的杏仁核网络中观察到中断。
Generalized anxiety disorder (GAD) typically begins during adolescence and can persist into adulthood. The pathophysiological mechanisms underlying this disorder remain unclear. Recent evidence from resting state functional magnetic resonance imaging (R-fMRI) studies in adults suggests disruptions in amygdala-based circuitry; the present study examines this issue in adolescents with GAD. Resting state fMRI scans were obtained from 15 adolescents with GAD and 20 adolescents without anxiety who were group matched on age, sex, scanner, and intelligence. Functional connectivity of the centromedial, basolateral, and superficial amygdala subdivisions was compared between groups. We also assessed the relationship between amygdala network dysfunction and anxiety severity. Adolescents with GAD exhibited disruptions in amygdala-based intrinsic functional connectivity networks that included regions in medial prefrontal cortex, insula, and cerebellum. Positive correlations between anxiety severity scores and amygdala functional connectivity with insula and superior temporal gyrus were also observed within the GAD group. There was some evidence of greater overlap (less differentiation of connectivity patterns) of the right basolateral and centromedial amygdala networks in the adolescents with, relative to those without, GAD. These findings suggest that adolescents with GAD manifest alterations in amygdala circuits involved in emotion processing, similar to findings in adults. In addition, disruptions were observed in amygdala-based networks involved in fear processing and the coding of interoceptive states.
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影响因子：
--
作者：
Guyer, Amanda E.;Lau, Jennifer Y. F.;McClure-Tone, Erin B.;Parrish, Jessica;Shiffrin, Nina D.;Reynolds, Richard C.;Chen, Gang;Blair, R. J. R.;Leibenluft, Ellen;Fox, Nathan A.;Ernst, Monique;Pine, Daniel S.;Nelson, Eric E.
通讯作者：
Nelson, Eric E.
影响因子：
19.9
作者：
Etkin, Amit;Egner, Tobias;Kalisch, Raffael
通讯作者：
Kalisch, Raffael
DOI：
10.1176/appi.ajp.2009.08121894
发表时间：
2009-08
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Di Martino A;Shehzad Z;Kelly C;Roy AK;Gee DG;Uddin LQ;Gotimer K;Klein DF;Castellanos FX;Milham MP
通讯作者：
Milham MP
影响因子：
2.3
作者：
Hoehn-Saric, R;Schlund, MW;Wong, SHY
通讯作者：
Wong, SHY
影响因子：
17.7
作者：
Monk, Christopher S.;Nelson, Eric E.;Pine, Daniel S.
通讯作者：
Pine, Daniel S.