Fourier transform infrared imaging of femoral neck bone: reduced heterogeneity of mineral-to-matrix and carbonate-to-phosphate and more variable crystallinity in treatment-naive fracture cases compared with fracture-free controls.
Fourier transform infrared imaging of femoral neck bone: reduced heterogeneity of mineral-to-matrix and carbonate-to-phosphate and more variable crystallinity in treatment-naive fracture cases compared with fracture-free controls.
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DOI：
10.1002/jbmr.1724
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发表时间：
2013-01
影响因子：
6.2
通讯作者：
Boskey, Adele L.
中科院分区：
文献类型：
--
作者：
Gourion-Arsiquaud, Samuel;Lukashova, Lyudmilla;Power, Jon;Loveridge, Nigel;Reeve, Jonathan;Boskey, Adele L.
关键词：
60岁以后，髋部骨折的风险大大增加，但只有五分之一的增加是由于矿物质密度（BMD，临床测量）降低。骨质量的变化，特别是通过傅立叶变换红外光谱成像（FTIRI）测量的骨成分，也会导致骨折风险。在这里，傅里叶变换红外成像技术被应用于研究股骨颈，并提供空间派生的信息，其矿物和基质的属性，在年龄匹配的骨折和非骨折的骨头。应用傅里叶变换红外成像（FTIRI）技术和显微计算机断层扫描技术，对10例女性髋部骨折患者和10例正常人股骨颈全断面进行了研究。虽然三维微CT骨密度相似，但在髋部骨折病例中，矿物质与基质的比例降低，证实了先前的报告。新的发现是，FTIRI微观变化（异质性）的矿物基质比大幅减少在骨折组的碳酸盐-磷酸盐比的异质性。相反，结晶度的不均匀性增加。结晶度的变化增加与碳酸盐与磷酸盐比率的变化减少在统计学上相关。与对照组相比，骨折组不同股骨颈象限之间这些特性的解剖变异减少。虽然我们的治疗初治患者的抗弯强度降低而不是增加，但与髋部骨折相关的异质性变化在另一方面与实验性双膦酸盐治疗的效果相当，其降低了异质性和骨韧性的其他指标。
After age 60 hip fracture risk strongly increases, but only a fifth of this increase is attributable to reduced mineral density (BMD, measured clinically). Changes in bone quality, specifically bone composition as measured by Fourier Transform Infrared spectroscopic imaging (FTIRI), also contribute to fracture risk. Here, FTIRI was applied to study the femoral neck and provide spatially derived information on its mineral and matrix properties in age-matched fractured and non-fractured bones. Whole femoral neck cross sections, divided into quadrants along the neck’s axis, from 10 women with hip fracture and 10 cadaveric controls were studied using FTIRI and micro-computed Tomography. Although 3-dimensional micro-CT bone mineral densities were similar, the mineral-to-matrix ratio was reduced in the cases of hip fracture, confirming previous reports. New findings were that the FTIRI microscopic variation (heterogeneity) of the mineral-to-matrix ratio was substantially reduced in the fracture group as was the heterogeneity of the carbonate-to-phosphate ratio. Conversely, the heterogeneity of crystallinity was increased. Increased variation of crystallinity was statistically associated with reduced variation of the carbonate-to-phosphate ratio. Anatomical variation in these properties between the different femoral neck quadrants was reduced in the fracture group compared to controls. While our treatment-naïve patients had reduced rather than increased bending resistance, these changes in heterogeneity associated with hip fracture are in another way comparable to the effects of experimental bisphosphonate therapy, which decreases heterogeneity and other indicators of bone’s toughness as a material.
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影响因子：
4.1
作者：
Gourion-Arsiquaud, Samuel;Allen, Matthew R.;Burr, David B.;Vashishth, Deepak;Tang, Simon Y.;Boskey, Adele L.
通讯作者：
Boskey, Adele L.
影响因子：
4.1
作者：
Busse, Bjoern;Hahn, Michael;Amling, Michael
通讯作者：
Amling, Michael
影响因子：
29.4
作者：
Fratzl, Peter;Gupta, Himadri S.;Kolednik, Otmar
通讯作者：
Kolednik, Otmar
影响因子：
6.2
作者：
Durchschlag, Erich;Paschalis, Eleftherios P.;Klaushofer, Klaus
通讯作者：
Klaushofer, Klaus
影响因子：
4.2
作者：
Fratzl-Zelman, N.;Roschger, P.;Gourrier, A.;Weber, M.;Misof, B. M.;Loveridge, N.;Reeve, J.;Klaushofer, K.;Fratzl, P.
通讯作者：
Fratzl, P.