Roles of Macrophages in the Development and Treatment of Gut Inflammation.
Roles of Macrophages in the Development and Treatment of Gut Inflammation.
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巨噬细胞在肠道炎症的发生和治疗中的作用
DOI：
10.3389/fcell.2021.625423
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发表时间：
2021
影响因子：
5.5
通讯作者：
Liu G
中科院分区：
文献类型：
--
作者：
Han X;Ding S;Jiang H;Liu G
巨噬细胞是具有功能可塑性的细胞，能够吞噬和消化外来物质，并根据其微环境获得促炎（M1样）或抗炎（M2样）表型。肠道中大量的巨噬细胞在维持肠黏膜表面微生物的内稳态以及肠上皮细胞的持续更新方面发挥着重要作用。它们不仅负责先天免疫，还参与肠道炎症的发生发展。清楚地了解巨噬细胞的功能以及它们在病原体和炎症反应中的作用，将为肠道炎症性疾病的治疗指明下一步方向。在这篇综述中，我们讨论了巨噬细胞的起源和发育以及它们在肠道炎症反应或感染中的作用。此外，本文还综述了巨噬细胞在炎症性肠病（IBD）发生和发展中的作用，以及它们在诱导纤维化、激活T细胞、减轻结肠炎和治疗肠道炎症方面的作用。
Macrophages, which are functional plasticity cells, have the ability to phagocytize and digest foreign substances and acquire pro-(M1-like) or anti-inflammatory (M2-like) phenotypes according to their microenvironment. The large number of macrophages in the intestinal tract, play a significant role in maintaining the homeostasis of microorganisms on the surface of the intestinal mucosa and in the continuous renewal of intestinal epithelial cells. They are not only responsible for innate immunity, but also participate in the development of intestinal inflammation. A clear understanding of the function of macrophages, as well as their role in pathogens and inflammatory response, will delineate the next steps in the treatment of intestinal inflammatory diseases. In this review, we discuss the origin and development of macrophages and their role in the intestinal inflammatory response or infection. In addition, the effects of macrophages in the occurrence and development of inflammatory bowel disease (IBD), and their role in inducing fibrosis, activating T cells, reducing colitis, and treating intestinal inflammation were also reviewed in this paper.
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影响因子：
2.3
作者：
Bettenworth, Dominik;Rieder, Florian
通讯作者：
Rieder, Florian
DOI：
10.1084/jem.20170057
发表时间：
2018-02-05
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Bujko A;Atlasy N;Landsverk OJB;Richter L;Yaqub S;Horneland R;Øyen O;Aandahl EM;Aabakken L;Stunnenberg HG;Bækkevold ES;Jahnsen FL
通讯作者：
Jahnsen FL
影响因子：
30.5
作者：
通讯作者：
--
影响因子：
8.7
作者：
Bain CC;Mowat AM
通讯作者：
Mowat AM
影响因子：
4.9
作者：
Brynjolfsson, Siggeir F.;Magnusson, Maria K.;Wick, Mary Jo
通讯作者：
Wick, Mary Jo