APOE ε4-Allele in Middle-Aged and Older Autistic Adults: Associations with Verbal Learning and Memory.
APOE ε4-Allele in Middle-Aged and Older Autistic Adults: Associations with Verbal Learning and Memory.
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APOE ε4等位基因在中老年自闭症患者中的作用：与语言学习和记忆的关系
DOI：
10.3390/ijms242115988
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发表时间：
2023-11-05
影响因子：
5.6
通讯作者：
中科院分区：
文献类型：
--
作者：
自闭症谱系障碍(ASD)是一种神经发育障碍，最近的证据表明，与神经典型(NT)成年人相比，自闭症成年人更容易患上阿尔茨海默病(ALZ)和其他痴呆。载脂蛋白E(ApoE)基因的ε4等位基因是阿尔茨海默病最强的遗传危险因素，对中老年人(MA+)的认知有负面影响。本研究旨在确定ε4等位基因对MA+自闭症成人(40-71岁)言语学习和记忆的影响，并与匹配的NT成年人进行比较。使用听觉词汇学习测验，我们发现ε4携带者在短时记忆和词汇学习方面表现较差，但与诊断没有交互作用。在性行为组和诊断组的探索性分析中，只有携带载脂蛋白ε4的自闭症男性比非携带者的自闭症男性表现出更差的语言学习(p=0.02)。最后，在这个样本中，载脂蛋白Eε4等位基因对长期记忆没有显著影响。这些发现重复了之前的工作，即载脂蛋白Eε4等位基因对MA+成年人的短期记忆和语言学习产生负面影响，并提出了新的初步发现，即MA+自闭症男性可能容易受到载脂蛋白ε4对语言学习的影响。未来需要进行更大样本的研究，以确定自闭症女性是否也可能是脆弱的。
Autism spectrum disorder (ASD) is a neurodevelopmental disability and recent evidence suggests that autistic adults are more likely to develop Alzheimer’s disease (Alz) and other dementias compared to neurotypical (NT) adults. The ε4-allele of the Apolipoprotein E (APOE) gene is the strongest genetic risk factor for Alz and negatively impacts cognition in middle-aged and older (MA+) adults. This study aimed to determine the impact of the APOE ε4-allele on verbal learning and memory in MA+ autistic adults (ages 40–71 years) compared to matched NT adults. Using the Auditory Verbal Learning Test (AVLT), we found that ε4 carriers performed worse on short-term memory and verbal learning across diagnosis groups, but there was no interaction with diagnosis. In exploratory analyses within sex and diagnosis groups, only autistic men carrying APOE ε4 showed worse verbal learning (p = 0.02), compared to autistic men who were not carriers. Finally, the APOE ε4-allele did not significantly affect long-term memory in this sample. These findings replicate previous work indicating that the APOE ε4-allele negatively impacts short-term memory and verbal learning in MA+ adults and presents new preliminary findings that MA+ autistic men may be vulnerable to the effects of APOE ε4 on verbal learning. Future work with a larger sample is needed to determine if autistic women may also be vulnerable.
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影响因子：
2.5
作者：
Braden, B. Blair;Riecken, Cory
通讯作者：
Riecken, Cory
患有自闭症的男性和女性的认知：相似性和差异。
影响因子：
3.7
作者：
Lai MC;Lombardo MV;Ruigrok AN;Chakrabarti B;Wheelwright SJ;Auyeung B;Allison C;MRC AIMS Consortium;Baron-Cohen S
通讯作者：
Baron-Cohen S
DOI：
10.1186/s13195-017-0300-8
发表时间：
2017-09-12
期刊：
Alzheimer's research & therapy
影响因子：
--
作者：
Caldwell JZK;Berg JL;Cummings JL;Banks SJ;Alzheimer’s Disease Neuroimaging Initiative
通讯作者：
Alzheimer’s Disease Neuroimaging Initiative
影响因子：
3.4
作者：
Crawford, John R.;Garthwaite, Paul H.
通讯作者：
Garthwaite, Paul H.
DOI：
10.1186/s13195-020-00712-4
发表时间：
2020-11-04
期刊：
Alzheimer's research & therapy
影响因子：
--
作者：
Emrani S;Arain HA;DeMarshall C;Nuriel T
通讯作者：
Nuriel T