The role of mild stressors in children's cognition and inflammation: positive and negative impacts depend on timing of exposure.
The role of mild stressors in children's cognition and inflammation: positive and negative impacts depend on timing of exposure.
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DOI：
10.1192/j.eurpsy.2023.2468
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发表时间：
2023-10-26
影响因子：
7.8
通讯作者：
Flouri, Eirini
中科院分区：
文献类型：
--
作者：
Francesconi, Marta;Minichino, Amedeo;Flouri, Eirini
虽然压力生活事件（SLEs）对心理健康的影响是公认的，但对这些压力源对认知结果的影响的研究产生了不同的结果。可以说，暴露的时间和严重程度可能起着关键作用。在这项研究中，我们揭示了暴露于相对较小的SLEs的时间与儿童认知能力之间的关系，同时考虑到一个合理的生物介质的作用：炎症。使用来自雅芳父母和儿童纵向研究的数据，我们探索了相对较小的SLEs的作用，在两个关键的发展阶段经历：直到过渡到学校（1-4.5岁）和过渡到青春期（5.5-8.5岁）。然后，我们测试了它们是否会对9岁时的炎症标志物（血清c -反应蛋白[CRP]和白细胞介素6 [IL-6]）和15岁时的一般智力（用韦氏简略智力量表测量）产生不同的影响。在控制协变量的情况下，使用通径分析对数据（n = 4,525）进行分析。我们发现，在进入学校之前经历相对较小的压力事件时，他们在15岁时具有较高的智商，而在进入青春期之前经历相对较小的压力事件时，他们在9岁时具有较高的IL-6水平。相关协变量（包括8岁时的智商）的校正结果是稳健的。儿童时期的轻度压力源可能导致积极（即认知能力的提高）或消极（即炎症）的结果，这取决于暴露的时间。
Although the impact of stressful life events (SLEs) on mental health is well-established, the research on the impact of such stressors on cognitive outcomes has produced mixed results. Arguably, the timing and severity of exposure may play a key role. In this study, we shed light on the relationship between timing of exposure to relatively minor SLEs and cognitive ability in children, while taking into account the role of a plausible biological mediator: inflammation. Using data from the Avon Longitudinal Study of Parents and Children, a general population birth cohort, we explored the role of relatively minor SLEs, experienced during two crucial developmental stages: up to transition to school (1–4.5 years) and up to transition to puberty (5.5–8.5 years). We then tested if they may impact differently on inflammatory markers (serum C-reactive protein [CRP] and interleukin 6 [IL-6]) at age 9 and general intelligence, measured with the Wechsler Abbreviated Scale of Intelligence at age 15. Data (n = 4,525) were analyzed using path analysis while controlling for covariates. We found that when relatively minor stressful events were experienced up to transition to school they were significantly associated with higher IQ at age 15, whereas when experienced up to transition to puberty they were significantly associated with higher levels of IL-6 at age 9. Results were robust to adjustment for relevant covariates, including IQ at age 8. Mild stressors in childhood may result in positive (i.e., improved cognition) or negative (i.e., inflammation) outcomes depending on the timing of exposure.
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影响因子：
6.6
作者：
Flouri, Eirini;Francesconi, Marta;Lewis, Glyn
通讯作者：
Lewis, Glyn
影响因子：
25.8
作者：
Khandaker GM;Pearson RM;Zammit S;Lewis G;Jones PB
通讯作者：
Jones PB
影响因子：
15.1
作者：
Flouri, Eirini;Francesconi, Marta;Lewis, Glyn
通讯作者：
Lewis, Glyn
影响因子：
4.5
作者：
Francesconi, Marta;Minichino, Amedeo;Flouri, Eirini
通讯作者：
Flouri, Eirini
学龄前年份的大脑发育。
影响因子：
5.8
作者：
Brown, Timothy T.;Jernigan, Terry L.
通讯作者：
Jernigan, Terry L.