Neural response to emotional stimuli during experimental human endotoxemia
Neural response to emotional stimuli during experimental human endotoxemia
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实验性人内毒素血症期间对情绪刺激的神经反应
DOI：
10.1002/hbm.22063
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发表时间：
2013
影响因子：
4.8
通讯作者：
Schedlowski M.
中科院分区：
文献类型：
--
作者：
Kullmann J.S;Grigoleit J.-S;Lichte P;Kobbe P;Rosenberger C;Banner C;Wolf O.T;Engler H;Oberbeck R;Elsenbruch S;Bingel U;Forsting M;Gizewski E.R;Schedlowski M.
急性炎症期间外周细胞因子的增加可能会影响各种神经心理功能。这项功能性磁共振成像 (fMRI) 研究的目的是研究急性内毒素血症对健康受试者情绪以及对情绪厌恶视觉刺激的神经反应的影响。在一项双盲、随机交叉研究中，18 名健康男性接受了细菌脂多糖（LPS；0.4 ng/kg）或盐水的推注。在呈现厌恶与中性图片期间，对促炎和抗炎细胞因子和皮质醇的血浆水平以及情绪评级以及血氧水平依赖性（BOLD）反应进行了分析。内毒素给药引起 TNF-α、IL-1ra、IL-6、IL-10 和皮质醇血浆水平显着短暂升高。积极情绪下降，状态焦虑增加。此外，在 LPS 条件下，右下眶额皮质 (OFC) 对情绪视觉刺激的激活显着增加。在呈现情绪材料期间前额叶激活的增加可能反映了情绪认知调节的增强，作为急性炎症期间的适应性反应。这些发现可能对炎症过程在抑郁症病理生理学中的假定作用产生影响。Hum Brain Mapp 34:2217–2227, 2013。© 2012 Wiley periodicals, Inc.
Increases in peripheral cytokines during acute inflammation may affect various neuropsychological functions. The aim of this functional magnetic resonance imaging (fMRI) study was to investigate the effects of acute endotoxemia on mood and the neural response to emotionally aversive visual stimuli in healthy human subjects. In a double‐blind, randomized crossover study, 18 healthy males received a bolus injection of bacterial lipopolysaccharide (LPS; 0.4 ng/kg) or saline. Plasma levels of pro‐ and anti‐inflammatory cytokines and cortisol as well as mood ratings were analyzed together with the blood‐oxygen‐level dependent (BOLD) response during the presentation of aversive versus neutral pictures. Endotoxin administration induced pronounced transient increases in plasma levels of TNF‐α, IL‐1ra, IL‐6, IL‐10, and cortisol. Positive mood was decreased and state anxiety increased. In addition, activation of right inferior orbitofrontal cortex (OFC) in response to emotional visual stimuli was significantly increased in the LPS condition. Increased prefrontal activation during the presentation of emotional material may reflect enhanced cognitive regulation of emotions as an adaptive response during an acute inflammation. These findings may have implications for the putative role of inflammatory processes in the pathophysiology of depression.Hum Brain Mapp 34:2217–2227, 2013. © 2012 Wiley Periodicals, Inc.
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影响因子：
3.7
作者：
Engel, SA;Glover, GH;Wandell, BA
通讯作者：
Wandell, BA
负面情绪图片的血流动力学影响——重测分析
影响因子：
3.2
作者：
R. Stark;A. Schienle;B. Walter;P. Kirsch;C. Blecker;U. Ott;Axel Schäfer;G. Sammer;Mark Zimmermann;D. Vaitl
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影响因子：
5.7
作者：
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通讯作者：
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影响因子：
6.6
作者：
Dichter, Gabriel S.;Felder, Jennifer N.;Smoski, Moria J.
通讯作者：
Smoski, Moria J.
影响因子：
3.7
作者：
Gross, JJ
通讯作者：
Gross, JJ