Inadequate intake of nutrients essential for neurodevelopment in children with fetal alcohol spectrum disorders (FASD).
Inadequate intake of nutrients essential for neurodevelopment in children with fetal alcohol spectrum disorders (FASD).
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DOI：
10.1016/j.ntt.2013.06.005
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发表时间：
2013-09
影响因子：
2.9
通讯作者：
Wozniak, Jeffrey R.
中科院分区：
文献类型：
--
作者：
Fuglestad, Anita J.;Fink, Birgit A.;Eckerle, Judith K.;Boys, Christopher J.;Hoecker, Heather L.;Kroupina, Maria G.;Zeisel, Steven H.;Georgieff, Michael K.;Wozniak, Jeffrey R.
本研究评估了胎儿酒精谱系障碍（FASD）儿童的饮食摄入量。临床前研究表明，营养补充剂可以减轻FASD的认知和行为缺陷。目前，FASD儿童必需营养素的膳食充足性尚不清楚。饮食数据是作为FASD患者补充胆碱的随机、双盲对照试验的一部分收集的。参与者包括31名FASD儿童，年龄在2.5 - 4.9岁。在为期9个月的研究中，通过访谈管理的24小时回忆与自动自我管理的24小时回忆，收集了三次饮食摄入量数据。在三个数据收集点，对食物中大量营养素和17种维生素/矿物质的膳食摄入量进行平均。将观察到的营养素摄入量与2 - 5岁儿童的全国膳食摄入量数据（我们在美国吃什么，NHANES 2007-2008）和膳食参考摄入量进行比较。与NHANES样本中儿童的膳食摄入量相比，FASD儿童的饱和脂肪、维生素D和钙摄入量较低。大多数（>50%）FASD儿童不符合纤维、n-3脂肪酸、维生素D、维生素E、维生素K、胆碱和钙的推荐膳食供给量（RDA）或充足摄入量（AI）。FASD儿童的这种饮食摄入模式表明，可能有机会从营养干预中获益。补充几种营养素，包括胆碱，维生素D和n-3脂肪酸，已在动物模型中显示，以减轻FASD的认知缺陷。这些结果突出了FASD营养临床试验的潜力。
This study evaluated dietary intake in children with fetal alcohol spectrum disorders (FASD). Pre-clinical research suggests that nutrient supplementation may attenuate cognitive and behavioral deficits in FASD. Currently, the dietary adequacy of essential nutrients in children with FASD is unknown. Dietary data were collected as part of a randomized, doubleblind controlled trial of choline supplementation in FASD. Participants included 31 children with FASD, ages 2.5 – 4.9 years at enrollment. Dietary intake data was collected three times during the nine month study via interview-administered 24-hour recalls with the Automated Self-Administered 24-hour Recall. Dietary intake of macronutrients and 17 vitamins/minerals from food were averaged across three data collection points. Observed nutrient intakes were compared to national dietary intake data of children ages 2 – 5 years (What we Eat in America, NHANES 2007–2008) and to the Dietary Reference Intakes. Compared to the dietary intakes of children in the NHANES sample, children with FASD had lower intakes of saturated fat, vitamin D, and calcium. The majority (>50%) of children with FASD did not meet the Recommended Dietary Allowance (RDA) or Adequate Intake (AI) for fiber, n-3 fatty acids, vitamin D, vitamin E, vitamin K, choline, and calcium. This pattern of dietary intake in children with FASD suggests that there may be opportunities to benefit from nutritional intervention. Supplementation with several nutrients including choline, vitamin D, and n-3 fatty acids, has been shown in animal models to attenuate the cognitive deficits of FASD. These results highlight the potential of nutritional clinical trials in FASD.
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影响因子：
2.9
作者：
Nyaradi A;Li J;Hickling S;Foster J;Oddy WH
通讯作者：
Oddy WH
DOI：
10.1016/j.jsbmb.2012.10.012
发表时间：
2013-07
影响因子：
4.1
作者：
Idrus, N. M.;Happer, J. P.;Thomas, J. D.
通讯作者：
Thomas, J. D.
影响因子：
5.6
作者：
Patten, Anna R.;Brocardo, Patricia S.;Christie, Brian R.
通讯作者：
Christie, Brian R.
影响因子：
2.9
作者：
Thomas, JD;Garrison, M;O'Neill, TM
通讯作者：
O'Neill, TM
影响因子：
4.2
作者：
Jacob, RA;Jenden, DJ;Swendseid, ME
通讯作者：
Swendseid, ME