Prognostic Value of Combination of Pretreatment Red Cell Distribution Width and Neutrophil-to-Lymphocyte Ratio in Patients with Gastric Cancer.
Prognostic Value of Combination of Pretreatment Red Cell Distribution Width and Neutrophil-to-Lymphocyte Ratio in Patients with Gastric Cancer.
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DOI：
10.1155/2018/8042838
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发表时间：
2018
影响因子：
2
通讯作者：
Zhang T
中科院分区：
文献类型：
--
作者：
Zhou D;Wu Y;Lin Z;Shi L;Zhao L;Liu T;Yu D;Zhang T
胃癌(GC)通常被诊断为晚期，目前尚无廉价有效的胃癌生物标志物。我们的目的是评估治疗前红细胞分布宽度(RDW)和中性粒细胞/淋巴细胞比率(NLR)联合检测对GC患者的预后。对2012-2016年间在我所就诊的103例胃癌患者进行了回顾性分析。根据建议的截止值分别为13.4%和2.755计算了前处理的RDW和NLR值。RDW和NLR(RDW + NLR)的合并值将患者分层为0分(RDW ≤ 13.4%和NLR ≤ 2.755)、1分(RDW &> 13.4%或NLR &> 2.755)和2分(RDW &> 13.4%和NLR &> 2.755)。评估总生存期(OS)和无进展生存期(PFS)的预后意义。治疗前RDW、 + 、NLR值是OS和PFS的独立预后因素。此外，高RDWNLR值与年龄、肿瘤部位、 + 分期、CA125CA199密切相关。在对进展期胃癌患者的亚组分析中，我们观察到RDW + NLR值与OS和PFS显著相关。RDW- + 是一种简单、廉价、有效的预后预测系统，可用于预测胃癌尤其是胃癌患者的生存。
Gastric cancer (GC) is often diagnosed at an advanced stage; inexpensive and valid biomarkers for GC are still unavailable. We aimed to evaluate the prognosis of the combination of pretreatment red cell distribution width (RDW) and neutrophil-to-lymphocyte ratio (NLR) in patients with GC. A retrospective analysis from 103 GC patients who were diagnosed at our institution from 2012 to 2016 was performed. Both pretreatment RDW and NLR were calculated based on the recommended cutoff values of 13.4% and 2.755, respectively. Combined values of RDW and NLR (RDW + NLR) stratified patients into a score of 0 (RDW ≤ 13.4% and NLR ≤ 2.755), a score of 1 (RDW > 13.4% or NLR > 2.755), and a score of 2 (RDW > 13.4% and NLR > 2.755). Prognostic significances for overall survival (OS) and progression-free survival (PFS) were assessed. Pretreatment RDW + NLR was a significantly independent prognostic factor for OS and PFS. Moreover, high RDW + NLR was strongly related to age, tumor location, TNM stage, CA125, and CA199. In a subgroup analysis for patients with advanced gastric cancer (AGC), we observed that the level of RDW + NLR was markedly associated with OS and PFS. Pretreatment RDW + NLR is a simple, inexpensive, and valid prognostic system to predict the survival in patients with GC, especially AGC.
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影响因子：
--
作者：
McCourt, M;Wang, JH;Redmond, HP
通讯作者：
Redmond, HP
非小细胞肺癌中嗜中性粒细胞与淋巴细胞比的预后意义：一项荟萃分析。
影响因子：
4.6
作者：
Gu XB;Tian T;Tian XJ;Zhang XJ
通讯作者：
Zhang XJ
影响因子：
--
作者：
Patel, Kushang V.;Ferrucci, Luigi;Ershler, William B.;Longo, Dan L.;Guralnik, Jack M.
通讯作者：
Guralnik, Jack M.
影响因子：
9
作者：
Chan JC;Chan DL;Diakos CI;Engel A;Pavlakis N;Gill A;Clarke SJ
通讯作者：
Clarke SJ
影响因子：
--
作者：
Hu L;Li M;Ding Y;Pu L;Liu J;Xie J;Cabanero M;Li J;Xiang R;Xiong S
通讯作者：
Xiong S