Simulation study of protoacoustics as a real-time in-line dosimetry tool for FLASH proton therapy.
Simulation study of protoacoustics as a real-time in-line dosimetry tool for FLASH proton therapy.
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原声学作为 FLASH 质子治疗的实时在线剂量测定工具的模拟研究。
DOI：
10.1002/mp.16894
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发表时间：
2023
期刊：
影响因子：
3.8
通讯作者：
Xiang,Liangzhong
中科院分区：
文献类型：
--
作者：
Kim,Kaitlyn;Pandey,PrabodhKumar;Gonzalez,Gilberto;Chen,Yong;Xiang,Liangzhong
背景与传统放射治疗相比，将超高剂量率应用于放射治疗（也称为 FLASH）已被证明同样有效，同时可以保护更多正常组织。然而，需要一种能够检测如此高的瞬时剂量的剂量计，特别是在体内。为了满足这一需求，引入了原声学，这是一种亚毫米级精度的体内范围验证方法。目的本工作的目的是证明使用原声学作为FLASH质子治疗期间体内实时监测方法的可行性，并通过多次模拟研究研究当每个脉冲的剂量和脉冲宽度变化时产生的原声信号。 通过蒙特卡罗工具箱 TOPAS 计算质子笔形束的分布。接下来，MATLAB 中的 k-Wave 工具箱用于执行原声模拟，其中输入初始质子剂量沉积来模拟声传播，该模型也用于重建。进行了涉及控制每脉冲剂量和脉冲宽度的模拟，并研究了原声重建的时间和空间分辨率。使用多束斑轮廓进行 3D 重建，以研究空间分辨率并确定原声学 3D 成像的可行性。结果我们的结果显示，每脉冲剂量的增加具有一致的线性关系，甚至达到 FLASH 考虑的速率。模拟和重建是在 0.1 至 10 μs 的脉冲宽度范围内进行的。结果显示了将原声信号与不同脉冲宽度进行卷积后质子束的特征。使用 8 cm × 8 cm 平面阵列成功地进行了 3D 重建，每个光束都可区分。这些仿真结果表明，使用原声学测量具有在患者治疗期间实时进行 FLASH 治疗体内剂量测定的潜力。结论通过这项仿真研究，通过观察每个脉冲的剂量和脉冲宽度等不同参数，验证和探索了原声学在 FLASH 治疗中的使用。 2D 和 3D 重建也已完成。这项研究展示了使用原声学的重要性，并提供了必要的信息，可以在临床环境中进一步探索。
BackgroundApplying ultra‐high dose rates to radiation therapy, otherwise known as FLASH, has been shown to be just as effective while sparing more normal tissue compared to conventional radiation therapy. However, there is a need for a dosimeter that is able to detect such high instantaneous dose, particularly in vivo. To fulfill this need, protoacoustics is introduced, which is an in vivo range verification method with submillimeter accuracy.PurposeThe purpose of this work is to demonstrate the feasibility of using protoacoustics as a method of in vivo real‐time monitoring during FLASH proton therapy and investigating the resulting protoacoustic signal when dose per pulse and pulsewidth are varied through multiple simulation studies.MethodsThe dose distribution of a proton pencil beam was calculated through a Monte Carlo toolbox, TOPAS. Next, the k‐Wave toolbox in MATLAB was used for performing protoacoustic simulations, where the initial proton dose deposition was inputted to model acoustic propagations, which were also used for reconstructions. Simulations involving the manipulation of the dose per pulse and pulsewidth were performed, and the temporal and spatial resolution for protoacoustic reconstructions were investigated as well. A 3D reconstruction was performed with a multiple beam spot profile to investigate the spatial resolution as well as determine the feasibility of 3D imaging with protoacoustics.ResultsOur results showed consistent linearity in the increasing dose‐per‐pulse, even up to rates considered for FLASH. The simulations and reconstructions were performed for a range of pulsewidths from 0.1 to 10 μs. The results show the characteristics of the proton beam after convolving the protoacoustic signal with the varying pulsewidths. 3D reconstruction was successfully performed with each beam being distinguishable using an 8 cm × 8 cm planar array. These simulation results show that measurements using protoacoustics has the potential for in vivo dosimetry in FLASH therapy during patient treatments in real time.ConclusionThrough this simulation study, the use of protoacoustics in FLASH therapy was verified and explored through observations of varying parameters, such as the dose per pulse and pulsewidth. 2D and 3D reconstructions were also completed. This study shows the significance of using protoacoustics and provides necessary information, which can further be explored in clinical settings.
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DOI：
--
发表时间：
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期刊：
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影响因子：
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